The Production of Tumor Necrosis Factor-α by Rat Basophilic Leukemia Cells with Triggering IgE Receptor

ISAO OHNO; YASUO TANNO; KOHEI YAMAUCHI; SHIROH IDA; TAMOTSU TAKISHIMA

doi:10.1620/tjem.156.209

ISAO OHNO, YASUO TANNO, KOHEI YAMAUCHI, SHIROH IDA, TAMOTSU TAKISHIMA

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Keywords: basophil, mast cell, IgE receptor, cytotoxicity, tumor necrosis factor-α

JOURNAL FREE ACCESS

1988 Volume 156 Issue 2 Pages 209-210

DOI https://doi.org/10.1620/tjem.156.209

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Published: 1988 Received: March 09, 1988 Available on J-STAGE: August 31, 2006 Accepted: September 07, 1988 Advance online publication: - Revised: -
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Date of correction: August 31, 2006 Reason for correction: - Correction: ABSTRACT Details: Wrong : OHNO, I., TANNO, Y., YAMAUCHI, K., IDA, S. and TAKISHIMA, T. The Production of Tumor Necrosis Factor-α by Rat Basophilic Leukemia Cells with Triggering IgE Receptor. Tohoku J. exp. Med., 1988, 156 (2), 209-210 - We evaluated cytotoxic factor released from rat basophilic leukemia cells (RBL) sensitized with anti-ovalbumin (OVA) mouse serum after incubation with OVA. The cytotoxic activity of this factor was completely blocked by anti-mouse tumor necrosis factor-α (mTNF-α) specific antibody. Therefore, we concluded that by triggering the IgE receptor, RBL could produce and release TNF-α.
Right : We evaluated cytotoxic factor released from rat basophilic leukemia cells (RBL) sensitized with anti-ovalbumin (OVA) mouse serum after incubation with OVA. The cytotoxic activity of this factor was completely blocked by anti-mouse tumor necrosis factor-α (mTNF-α) specific antibody. Therefore, we concluded that by triggering the IgE receptor, RBL could produce and release TNF-α.

Date of correction: August 31, 2006 Reason for correction: - Correction: AFFILIATION Details: Wrong :
1) The First Department of Internal Meicine, Tohoku University School of Medicine

Right :
1) The First Department of Internal Medicine, Tohoku University School of Medicine

Date of correction: August 31, 2006 Reason for correction: - Correction: CITATION Details: Wrong : 1) Henderson, W.R., Chi, E.Y., Jong, E.C. & Klebanoff, S.J. (1981) Mast cell-mediated tumor-cell cytotoxicity. Role of the peroxidase system. J. exp. Med., 153, 520-533.
2) Kirstein, M., Friers, W. & Baglioni, C. (1986) Growth inhibition and cytotoxicity of tumor necrosis factor in L929 cells is enhanced by cell density and inhibition of mRNA synthesis. J. Immunol., 137, 2277-2280.
3) Okuno, T., Takagaki, Y., Pluznik, D.H. & Djeu, J.Y. (1986) Natural cytotoxic (NC) cell activity in basophilic cells: Release of NC-specific cytotoxic factor by IgE receptor triggering. J. Immunol., 136, 4652-4658.
4) Young, J.D., Liu, C., Butler, G., Chon, Z.A. & Galli, S.J. (1987) Identification, purification, and characterization of a mast cell-associated cytolytic factor related to tumor necrosis factor. Proc. nat. Acad. Sci. USA, 84, 9175-9179.

Right : 1) Henderson, W. R., Chi, E. Y., Jong, E. C. & Klebanoff, S. J. (1981) Mast cell-mediated tumor-cell cytotoxicity. Role of the peroxidase system. J. exp. Med., 153, 520-533.
2) Kirstein, M., Friers, W. & Baglioni, C. (1986) Growth inhibition and cytotoxicity of tumor necrosis factor in L929 cells is enhanced by cell density and inhibition of mRNA synthesis. J. Immunol., 137, 2277-2280.
3) Okuno, T., Takagaki, Y., Pluznik, D. H. & Djeu, J. Y. (1986) Natural cytotoxic (NC) cell activity in basophilic cells: Release of NC-specific cytotoxic factor by IgE receptor triggering. J. Immunol., 136, 4652-4658.
4) Young, J. D., Liu, C., Butler, G., Chon, Z. A. & Galli, S. J. (1987) Identification, purification, and characterization of a mast cell-associated cytolytic factor related to tumor necrosis factor. Proc. nat. Acad. Sci. USA, 84, 9175-9179.

Date of correction: August 31, 2006 Reason for correction: - Correction: PDF FILE Details: -

Abstract

We evaluated cytotoxic factor released from rat basophilic leukemia cells (RBL) sensitized with anti-ovalbumin (OVA) mouse serum after incubation with OVA. The cytotoxic activity of this factor was completely blocked by anti-mouse tumor necrosis factor-α (mTNF-α) specific antibody. Therefore, we concluded that by triggering the IgE receptor, RBL could produce and release TNF-α.

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