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Volume 156 (1988)
- Issue 4 Pages 305-
- Issue 3 Pages 211-
- Issue 2 Pages 101-
- Issue 1 Pages 1-
- Issue Suppl Pages 1-
Volume 156, Issue 2
Displaying 1-10 of 10 articles from this issue
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RYUICHI NAKAMURA, TORU HOSOKAWA, YOSHIAKI YAMADA, JOSE ALVIN, P. MOJIC ...1988 Volume 156 Issue 2 Pages 101-107
Published: 1988
Released on J-STAGE: August 31, 2006
JOURNAL FREE ACCESSThirteen hemiparetic stroke patients (experimental group) underwent the recently developed CAGT program during the early recovery phase, and their functional gain in walking capacity was compared with 17 other stroke patients (control group) being prescribed the conventional gait training program. Results showed that the recovery process of maximum walking speed after a stroke fitted the hyperbolic function in the experimental group and furthermore, the maximum walking speed that might be attained could be higher in the experimental than the control group. The CAGT program makes it possible to analyze and predict gait capacity, i.e., maximum walking speed, and to increase the functional gain of patients during early intensive physical therapy.View full abstractDownload PDF (985K) -
TAKASHI HORIE, CHIHARU OHMORI, SHOZO KOYAMA, OSAMU SAITOH, TAKASHI MUT ...1988 Volume 156 Issue 2 Pages 109-120
Published: 1988
Released on J-STAGE: August 31, 2006
JOURNAL FREE ACCESSWe have investigated the relationship between acute airway hyperresponsiveness and polymorphonuclear cell (PMN) migration in airways following saline or endotoxin (ET) aerosol inhalation in 63 guinea pigs. In 20 of these animals, granulocytopenia was induced by prior treatment with hydroxyurea (HU). Airway responsiveness (AR) to inhaled methacholine, together with leukocyte counts in bronchoalveolar lavage fluid (BALF) and in tracheal epithelium, was also examined before and at 30 min, 1, 3 and 6 hr after saline or ET inhalation. In saline inhalation groups, AR and PMN counts in BALF and in tracheal epithelium did not differ from control animals at any time points. However, in ET inhalation groups AR increased significantly at 1 and 3 hr and returned to the pre-exposure level at 6 hr. This period of hyperresponsiveness was associated with an increment of PMN migration into tracheal epithelium. However, the increment of PMN counts in BALF was delayed to 3 and 6 hr after ET. In HU treated animals, AR and PMN counts in BALF and in tracheal epithelium did not change during 6 hr after ET inhalation. These results suggest that the hyperresponsiveness induced by ET inhalation either depends upon PMN migration into the tracheal epithelium.View full abstractDownload PDF (811K) -
HITOSHI YOKOYAMA, JUN-ICHI IMAGAWA, KEISUKE SATOH, NORIO TAIRA, NOBUAK ...1988 Volume 156 Issue 2 Pages 121-134
Published: 1988
Released on J-STAGE: August 31, 2006
JOURNAL FREE ACCESSIsolated dog whole heart preparations run by means of cross-circulation with support dogs were prepared in two different ways. In one way the donors' hearts were quickly removed, and cannulation of their major vessels, insertion of a latex balloon into the left ventricle, etc. were all done in cold Tyrode solution in the condition of heart-anoxia within 30 min and then reperfused with arterial blood of support dogs (Group A). In the other, cannulation of the major vessels of the donors' hearts were done in the state of “beating heart” (Group B). In these two kinds of preparations we compared basal cardiocoronary measurements (coronary blood flow, left ventricular pressure (LVP), its first derivative (LV dP/dt) and myocardial oxygen consumption (MVO2) and ultrastructure of the myocardium at various periods of the experiments. There were no significant differences in these cardio-coronary measurements and ultrastructural findings. Furthermore, Group A preparations kept stable levels of cardio-coronary measurements for 5 hr or more and responded normally to isoproterenol. Therefore, isolated, blood-perfused dog whole hearts prepared in cold Tyrode solution and reperfused by means of the cross-circulation method would be useful for physiological, pharmacological and biochemical studies.View full abstractDownload PDF (3935K) -
HITOSHI KANDA, TAKASHI HANEDA, JUN IKEDA, TETSUYA HIRAMOTO, MOTOYUKI F ...1988 Volume 156 Issue 2 Pages 135-148
Published: 1988
Released on J-STAGE: August 31, 2006
JOURNAL FREE ACCESSAlthough a progressive reduction in left ventricular contractility during sustained left stellate ganglion stimulation has been well documented, there have been no reports on the contractile state after nerve stimulation. Left ventricular contractility after cessation of 60 min of electrical (10 V, 10 Hz, 1 msec) left stellate ganglion stimulation has been assessed in open chest dogs. Before and 15 min after stimulation, left ventricular contractility was evaluated by the end-systolic pressure-segment length relationship using ultrasonic crystals during a stepwise aortic constriction to increase left ventricular afterload. Restimulation of the left stellate ganglion was also performed 15 min after cessation of the first stimulation. After sustained left stellate ganglion stimulation, the end-systolic points shifted to the right from the control and the slope of multiple pressure-segment length coordinates significantly decreased (102.5±16.1 to 76.5±10.2mmHg/mm, mean±S. E., p < 0.05, n=5), indicating a depression of left ventricular contractility. Increased left ventricular dP/dt max and norepinephrine level in the coronary sinus gradually returned to near base line during 60 min of stimulation. These reduced responses lasted for at least 15 min after cessation of stimulation. The myocardial norepinephrine content was reduced to 0.59±0.08 (mean±S. E.) ng/mg wet tissue from 0.90±0.15 of the control level (p < 0.05). These data suggested that left ventricular contractility decreased after sustained cardiac sympathetic nerve stimulation, probably due to norepinephrine reduction in the myocardium.View full abstractDownload PDF (1573K) -
TADASHI TERUI, RYUJI SUZUKI, KATSUO KUMAGAI, HIDEAKI TAKEMATSU, TAIZO ...1988 Volume 156 Issue 2 Pages 149-156
Published: 1988
Released on J-STAGE: August 31, 2006
JOURNAL FREE ACCESSIn the previous report we found that IL-1-like activity in horny tissue extracts from patients with psoriasis vulgaris and related sterile pustular dermatoses was remarkably low as compared to that in orthokeratotic horny tissue extracts prepared from non-inflammatory skin. In this report we studied the inhibitory activity of lesional horny tissue extracts from three psoriatics on recombinant IL-1-induced thymocyte proliferation in order to search for a possible coexistence of substances which may inhibit thymocyte proliferation. However, we failed to demonstrate any remarkable IL-1 inhibitory activity in each fraction after gel filtration high-performance liquid chromatography of the psoriatic scale extracts or in that of extracts from the plantar callus. We conclude that IL-1 stores are decreased in the pathologic horny layers of psoriatic lesions.View full abstractDownload PDF (514K) -
REIKO DEMURA, TOMOHARU SUZUKI, SAEKO NAKAMURA, HIROMI KOMATSU, HIROSHI ...1988 Volume 156 Issue 2 Pages 157-163
Published: 1988
Released on J-STAGE: August 31, 2006
JOURNAL FREE ACCESSTo investigate a mode and a site of action of inhibin on FSH and LH secretion, in vivo and in vitro effects of porcine follicular fluid (PFF) on FSH and LH secretion were studied in male rats. PFF administerd i.v. suppressed basal FSH levels for 1-8 hr, but did not alter LH levels. On the contrary, PFF given either 1 or 6 hr in advance, suppressed LH-RH stimulated LH responses as well as LH-RH induced FSH responses. In cultured pituitary cells PFF exerted a partial suppressive effect on LH release. PFF suppressed LH release only under the maximal stimulation with 10-10 M LH-RH and 0.1mM 3-isobutyl-1-metylxanthine (IBMX) to a lesser degree compared with uniform and greater suppression on FSH release regardless of the experimental conditions. Above results showed a selective suppressive effect of PFF on FSH release and synthesis with a less inhibitory effect on LH release mainly at the pituitary level.View full abstractDownload PDF (401K) -
TAKEO TAKAHASHI, KAZUYOSHI KATAOKA, YASUO TSUKAHARA1988 Volume 156 Issue 2 Pages 165-173
Published: 1988
Released on J-STAGE: August 31, 2006
JOURNAL FREE ACCESSPower spectrum of photic driving elicited by 5/sec flickering dot pattern (FDP) and 5/sec red flicker (RF) stimuli was investigated in 137 psychiatric outpatients. They consisted of 61 adults (33 males and 28 females) from 20 to 44 years of age, 55 preseniles (25 males and 30 females) from 45 to 64 years and 21 seniles (9 males and 12 females) over 65 years of age. Powers of 5 and 10/sec photic driving elicited by FDP and RF stimuli were greater than those of the other higher harmonics and increased significantly with age. When such a finding was compared in relation to gender, significant increase of power with age was found for 5 and 10/sec photic driving elicited by both stimuli in females, whereas it was found only for 5/sec photic driving elicited by RF stimulation in males. Our findings suggest that the visual system of older female patients is very responsive not only to patterned stimuli but also to red flicker stimulation.View full abstractDownload PDF (627K) -
HIROSHI WATANABE, HIROSHI WASHIOKA, AKIRA TONOSAKI1988 Volume 156 Issue 2 Pages 175-190
Published: 1988
Released on J-STAGE: August 31, 2006
JOURNAL FREE ACCESSPlasmamembrane and its cytoskeletal undercoat were characterized by electron microscopy in gap junctions (GJs) of steroidogenic cells of the guinea pig and bullfrog adrenal glands. In both species GJs varied in shape considerably and measured 0.1-4 μm in diameter. Planar GJs were not provided with any distinct form of the undercoat. In contrast, variably invaginating GJs had a network of actin-containing microfilaments located in the protruding cytoplasm arising from either one of adjoining cells. In the deeper invaginations, on the contrary, parallel arrays of actin-containing microfilaments formed a submembranous sheath in the withdrawing cytoplasm. The microfilaments were arranged at right angles for the long axis of the invagination. In completely internalized GJs, the network and sheath became less organized or obscured. A mechanical force driving the invagination-endocytosis involving GJ areas is presumably generated by the microfilament network and sheath, organized differently in forms, but working in concert together. It is also likely that there is another dissolving process for GJs via clathrin-coated vesicles.View full abstractDownload PDF (7564K) -
MASATO NOGUCHI, KENICHI TAKAHASHI, HIROSHI OKAMOTO1988 Volume 156 Issue 2 Pages 191-207
Published: 1988
Released on J-STAGE: August 31, 2006
JOURNAL FREE ACCESSPeptidylglycine α-amidating activities from rat pituitary, brain and small intestine were compared, utilizing C-terminal analogues of vasoactive intestinal polypeptide (VIP), D-Tyr-Leu-Asn-Gly and D-Tyr-Asn-Gly, and C-terminal analogue of α-MSH, D-Tyr-Val-Gly. The three tissues had enzymic activities capable of converting the glycine-extended peptides to the corresponding α-amidated ones. In other words, all of three peptides could serve as substrates for the enzymes from both neural and gastrointestinal tissues. The activities were stimulated in the presence of copper and ascorbate; the optimal concentration of each cofactor was roughly equal for the three enzymes; similar pH profiles (a neutral pH optimum at 6.5-7 and another one at 8-8.5) were also observed. Desamide VIP-Gly was proved to be a potent inhibitor of the α-amidating activities from the tissues, but VIP was not, indicating that the α-amidating enzymes from these tissues in common have a recognition site for the C-terminal glycine of the glycine-extended precursor regardless of the length and nature of the sequence. No fundamental differences were observed between the catalytic properties of the α-amidating activities from these three tissues, raising the possibility that similar enzymes, which may or may not be a single species, are functioning in tissues that produce α-amidated polypeptides in vivo.View full abstractDownload PDF (1075K) -
ISAO OHNO, YASUO TANNO, KOHEI YAMAUCHI, SHIROH IDA, TAMOTSU TAKISHIMA1988 Volume 156 Issue 2 Pages 209-210
Published: 1988
Released on J-STAGE: August 31, 2006
JOURNAL FREE ACCESSWe evaluated cytotoxic factor released from rat basophilic leukemia cells (RBL) sensitized with anti-ovalbumin (OVA) mouse serum after incubation with OVA. The cytotoxic activity of this factor was completely blocked by anti-mouse tumor necrosis factor-α (mTNF-α) specific antibody. Therefore, we concluded that by triggering the IgE receptor, RBL could produce and release TNF-α.View full abstractDownload PDF (134K)
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