Effect of Intraoperative Radiotherapy on Pancreatic Carcinoma: Histopathological Findings from Autopsy Cases

NARIHIDE GOSEKI; MORIO KOIKE; ATSUTAKE OKAMOTO; TOKIO ONODERA; TADAYOSHI MATSUDA

doi:10.1620/tjem.156.211

NARIHIDE GOSEKI, MORIO KOIKE, ATSUTAKE OKAMOTO, TOKIO ONODERA, TADAYOSHI MATSUDA

Author information

Keywords: intraoperative radiotherapy (IOR), pancreatic cancer, pathological study, autopsy

JOURNAL FREE ACCESS

1988 Volume 156 Issue 3 Pages 211-219

DOI https://doi.org/10.1620/tjem.156.211

Details

Published: 1988 Received: March 24, 1988 Available on J-STAGE: August 31, 2006 Accepted: August 26, 1988 Advance online publication: - Revised: -
Correction information
Date of correction: August 31, 2006 Reason for correction: - Correction: ABSTRACT Details: Wrong : GOSEKI, N., KOIKE, M., OKAMOTO, A., ONODERA, T. and MATSUDA, T. Effect of Intraoperative Radiotherapy on Pancreatic Carcinoma: Histopathological Findings from Autopsy Cases. Tohoku J. exp. Med., 1988, 156 (3), 211-219 -Histopathological examinations of 18 necropsy patients with pancreatic carcinoma who died after receiving intraoperative radiotherapy (IOR) revealed the following: 1) Cancer cells were suspected of remaining in the periphery of the irradiated areas. 2) Thickening of intima of small arteries, some of which were obstructed, was found in the tumor tissues. 3) Highly degenerated nerve fibers were observed within the necrotic or viable tumor tissues. These findings provide evidence of the effects of IOR, while they also demonstrate the problems encountered in improving this treatment and the necessity of a complementary therapy for complete local control of pancreatic cancer by IOR.
Right : Histopathological examinations of 18 necropsy patients with pancreatic carcinoma who died after receiving intraoperative radiotherapy (IOR) revealed the following: 1) Cancer cells were suspected of remaining in the periphery of the irradiated areas. 2) Thickening of intima of small arteries, some of which were obstructed, was found in the tumor tissues. 3) Highly degenerated nerve fibers were observed within the necrotic or viable tumor tissues. These findings provide evidence of the effects of IOR, while they also demonstrate the problems encountered in improving this treatment and the necessity of a complementary therapy for complete local control of pancreatic cancer by IOR.

Date of correction: August 31, 2006 Reason for correction: - Correction: AFFILIATION Details: Wrong :
1) Department of Surgery, Tokyo Metropolitan Komagome Hospital
2) Department of Pathology, Tokyo Metropolitan Komagome Hospital
3) Department of Radiology, Tokyo Metropolitan Komagome Hospital
4) the First Department of Surgery, School of Medicine

Right :
1) Department of Surgery, Tokyo Metropolitan Komagome Hospital
2) Department of Pathology, Tokyo Metropolitan Komagome Hospital
3) Department of Radiology, Tokyo Metropolitan Komagome Hospital
4) the First Department of Surgery, School of Medicine, Tokyo Medical and Dental University

Date of correction: August 31, 2006 Reason for correction: - Correction: CITATION Details: Wrong : 1) Abe, M. & Takahashi, M. (1981) Intraoperative radiotherapy: Japanese experience. Int. J. radiat. Oncol. Biol. Phys., 7, 863-868.
2) Fortner, J.G. (1973) Regional resection of cancer of the pancreas: A new surgical approach. Surgery, 73, 307-320.
3) Goldson, A.L., Achaveri, E & Espinoza, M.C. (1981) Single high dose intraoperative electrons for advanced stage pancreatic cancer; Phase I pilot study. Int. J. radiat. Oncol. Biol. Phys., 7, 869-874.
4) Matsuda, T. (1986) Intraoperative radiotherapy in combination with computer controlled conformation radiotherapy for pancreatic cancer. In: Intraoperative Radiotherapy, edited by R.R. Dobelbower, CRC Press, Inc., Florida. (in press)
5) Monge, J.J., Judd, E.S. & Gawege, R.P. (1966) Radical pancreatoduodenectmy: A 22-year experience with the complication, mortality rate and survival rate. Ann. Surg., 160, 711-722.
6) Onodera, T., Okamoto, A., Ito, I. & Matsuda, T. (1981) Multimodal treatment for advanced cancer of the pancreas. World J. Surg., 5, 759-761.
7) Pliam, M.B. & ReMinem W.H. (1975) Further evaluation of total pancreatectomy. Arch. Surg., 110, 506-512.
8) Shipley, W.U., Wood, W.C., Tepper, J.E., Warshaw, A.L., Orlow, E.L., Kaufman, S.D., Battit, G.E. & Narrdi, G.L. (1984). Intraoperative electron beam irradiation for patients with unresectable pancreatic carcinoma. Ann. Surg., 200, 289-296.

Right : 1) Abe, M. & Takahashi, M. (1981) Intraoperative radiotherapy: Japanese experience. Int. J. radiat. Oncol. Biol. Phys., 7, 863-868.
2) Fortner, J. G. (1973) Regional resection of cancer of the pancreas: A new surgical approach. Surgery, 73, 307-320.
3) Goldson, A. L., Achaveri, E & Espinoza, M. C. (1981) Single high dose intraoperative electrons for advanced stage pancreatic cancer ; Phase I pilot study. Int. J. radiat. Oncol. Biol. Phys., 7, 869-874.
4) Matsuda, T. (1986) Intraoperative radiotherapy in combination with computer controlled conformation radiotherapy for pancreatic cancer. In: Intraoperative Radiotherapy, edited by R. R. Dobelbower, CRC Press, Inc., Florida. (in press)
5) Monge, J. J., Judd, E. S. & Gawege, R. P. (1966) Radical pancreatoduodenectmy: A 22-year experience with the complication, mortality rate and survival rate. Ann. Surg., 160, 711-722.
6) Onodera, T., Okamoto, A., Ito, I. & Matsuda, T. (1981) Multimodal treatment for advanced cancer of the pancreas. World J. Surg., 5, 759-761.
7) Pliam, M. B. & ReMinem W. H. (1975) Further evaluation of total pancreatectomy. Arch. Surg., 110, 506-512.
8) Shipley, W. U., Wood, W. C., Tepper, J. E., Warshaw, A. L., Orlow, E. L., Kaufman, S. D., Battit, G. E. & Narrdi, G. L. (1984). Intraoperative electron beam irradiation for patients with unresectable pancreatic carcinoma. Ann. Surg., 200, 289-296.

Date of correction: August 31, 2006 Reason for correction: - Correction: PDF FILE Details: -

Abstract

Histopathological examinations of 18 necropsy patients with pancreatic carcinoma who died after receiving intraoperative radiotherapy (IOR) revealed the following: 1) Cancer cells were suspected of remaining in the periphery of the irradiated areas. 2) Thickening of intima of small arteries, some of which were obstructed, was found in the tumor tissues. 3) Highly degenerated nerve fibers were observed within the necrotic or viable tumor tissues. These findings provide evidence of the effects of IOR, while they also demonstrate the problems encountered in improving this treatment and the necessity of a complementary therapy for complete local control of pancreatic cancer by IOR.

Corresponding author

Correction information

Register with J-STAGE for free!