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Volume 156 (1988)
- Issue 4 Pages 305-
- Issue 3 Pages 211-
- Issue 2 Pages 101-
- Issue 1 Pages 1-
- Issue Suppl Pages 1-
Volume 156, Issue 3
Displaying 1-11 of 11 articles from this issue
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NARIHIDE GOSEKI, MORIO KOIKE, ATSUTAKE OKAMOTO, TOKIO ONODERA, TADAYOS ...1988 Volume 156 Issue 3 Pages 211-219
Published: 1988
Released on J-STAGE: August 31, 2006
JOURNAL FREE ACCESSHistopathological examinations of 18 necropsy patients with pancreatic carcinoma who died after receiving intraoperative radiotherapy (IOR) revealed the following: 1) Cancer cells were suspected of remaining in the periphery of the irradiated areas. 2) Thickening of intima of small arteries, some of which were obstructed, was found in the tumor tissues. 3) Highly degenerated nerve fibers were observed within the necrotic or viable tumor tissues. These findings provide evidence of the effects of IOR, while they also demonstrate the problems encountered in improving this treatment and the necessity of a complementary therapy for complete local control of pancreatic cancer by IOR.View full abstractDownload PDF (3458K) -
SHIGEO TOMURA, YOSHIKO CHIDA, TAKASHI IDA, KENJIRO TANOUE, TAKESHI MOT ...1988 Volume 156 Issue 3 Pages 221-227
Published: 1988
Released on J-STAGE: August 31, 2006
JOURNAL FREE ACCESSTotal platelet adenosine diphosphate (ADP) and adenosine triphosphate (ATP) contents and amounts of ADP and ATP released from platelets by 3 μg/ml of collagen were studied in 20 patients with primary glomerular disease (PGD) to examine the metabolism of these platelet substances in the disease. ADP and ATP were measured by Holmsen's firefly luciferase method. The patients had significantly lower total platelet ATP compared with controls and total platelet ATP was significantly lower in nephrotic patients than in patients whose serum albumin levels were normal. Releasable platelet ADP and ATP were both significantly decreased in patients. Releasable ADP: total ADP ratio and releasable ATP: total ATP ratio were both significantly lower in patients' platelets than in normal platelets. There was no significant difference in platelet counts between patients and controls. Platelet aggegation induced by ADP and adrenaline were significantly higher in patients compared with controls. We conclude that total ATP content and the amount of ADP and ATP released by collagen are decreased in PGD patients' platelets.View full abstractDownload PDF (455K) -
TAKASHI SAKO, SHIGEO OHSHIMA, TAMOTSU YOSHIZUMI, MINORU SAKURAI1988 Volume 156 Issue 3 Pages 229-236
Published: 1988
Released on J-STAGE: August 31, 2006
JOURNAL FREE ACCESSBryostatin 1, a macrocyclic lactone, activated protein kinase C purified from mouse brain in a dose-dependent fashion to the same degree as phorbol 12-myristate 13-acetate (PMA). There was no significant difference in calcium and phosphatidylserine requirements for activation of protein kinase C between bryostatin 1 and PMA. We also found no significant difference in the inhibitory effect between staurosporine and H-7 known to be potent inhibitors of protein kinase C. These data suggest that bryostatin 1 and PMA activate protein kinase C in a similar way. We found, however, that negative modulation of protein kinase C with bryostatin 1 was weaker than that with PMA. The reason of this difference was unclear. It may possibly suggest that there is some difference in configuration of protein kinase C after binding between these activators.View full abstractDownload PDF (424K) -
MIKIO IMAMURA, HIDEMI YAMAUCHI, KOOHEI FUKUSHIMA, IWAO SASAKI, AKIO OU ...1988 Volume 156 Issue 3 Pages 237-249
Published: 1988
Released on J-STAGE: August 31, 2006
JOURNAL FREE ACCESSThe impairment of bone metabolism was investigated in patients who underwent gastrectomy or vagotomy with drainage two or more years ago. Serum biochemical analysis, microdensitometry of the 2nd metacarpal bone, and measurements of bone mineral content of the radius (measured 1/3 distally) using single-photon absorptiometry were performed at follow-up examination. Although serum levels of calcium, phosphorus and alkaline phosphatase were within normal range, alkaline phosphatase levels were slightly higher for the Billroth II group than for Billroth I. Twenty-eight of 50 gastrectomy cases (56%), and four of 10 vagotomy cases (40%) showed pathologically thin bone: microdensitometric (MD) scores were greater than 3. The Billroth II group showed a far higher frequency of greater MD scores than Billroth I. The MD scores showed significant positive relationship with the age at follow-up, but did not correlate well with the length of the postoperative period. Radial bone mineral content (BMC) was lower in patients with Billroth II anastomosis, or with total or proximal gastrectomy, than in those undergoing Billroth I. These results suggest that metabolic bone disorders following gastric surgery can be detected by MD score and BMC of appendicular bones. However, there was not sufficient resolution with these parameters to detect any bone changes in patients treated with active vitamin D3.View full abstractDownload PDF (771K) -
KIYOSHI AOYAGI, TAI-ICHIRO TAKEMOTO, KAZUHIKO MOJI1988 Volume 156 Issue 3 Pages 251-258
Published: 1988
Released on J-STAGE: August 31, 2006
JOURNAL FREE ACCESSThe cortical thickness of the clavicle (CTC), concentrations of bone gamma-carboxyglutamic acid-containing (Gla) protein (s-BGP, osteocalcin), alkaline phosphatase (s-ALP), calcium (s-Ca) and inorganic phosphorus (s-P) in serum, and calcium/creatinine (u-Ca/Cr) and inorganic phosphorus/creatinine (u-P/Cr) ratios in urine were examined in 211 subjects aged over 40 years in Oshima Island in Nagasaki prefecture. CTC decreased and s-BGP increased with age in both sexes, especially in women. Serum BGP was significantly higher in women than in men at the ages of 50's and over. Serum ALP in women increased until the ages of 60's. Serum Ca at the ages of 50's and s-P at the ages of 60's and over were higher in women than in men. As the increase in s-BGP is reported to be coincident with active bone formation, our findings do not support the view that age-related bone loss, especially in women, primarily results from decrease in bone formation.View full abstractDownload PDF (530K) -
TETSURO NISHIHIRA, TAKASHI TAKAGI, YOSHIKAZU KAWARABAYASHI, UICHIRO IZ ...1988 Volume 156 Issue 3 Pages 259-270
Published: 1988
Released on J-STAGE: August 31, 2006
JOURNAL FREE ACCESSFor the purpose of developing amino acid imbalance solution applicable to cancer treatment, we prepared seven kinds of amino acid imbalance solutions based on a 10% balanced amino acid solution and investigated the anti-tumor effects of each solution. The administration of valine-depleted amino acid solution for 8 days at a daily dose of 53 ml/rat (79.5 kcal/rat) resulted in the most significant inhibitory effects on the growth of hepatoma (AH109A) and mammary tumors (MRMT-1), the rate being 82.8% and 90.8%, respectively. Side effects observed were inhibition of increases in host body weight, weight loss of the spleen and thymus, loss of hair, and a decrease in the amounts of total plasma protein and albumin. When the daily dosage of valine-depleted amino acid solution was reduced to 40 ml/rat (58.3 kcal/rat), anti-tumor effects were still noticed, while side effects were abated. These findings indicate that side effects accompanying the use of this solution can be alleviated by controlling the ingredients of the solution as well as the amount administered. It is thus suggested that valine-depleted amino acid imbalance solution is a valuable tool in the treatment of cancer.View full abstractDownload PDF (697K) -
TSUTOMU IMAMURA, AKIO YASUDA, KEISUKE AMAHA1988 Volume 156 Issue 3 Pages 271-277
Published: 1988
Released on J-STAGE: August 31, 2006
JOURNAL FREE ACCESSArterial concentrations of given norepinephrine (NE) were measured after bolus administration in dogs with normal lungs and in those with oleic acid-induced lung edema. In both groups, the peak NE concentration was given by blood samples taken 30 sec after injection and the concentration showed a decreasing tendency thereafter. NE concentrations were always greater in the lung edema group than in the control group and a longer period was needed for NE concentrations to return to the baseline level. This delay in the clearance of NE from the circulation might reflect a diminished uptake by the pulmonary endothelium. This phenomenon may be used for the diagnosis of pulmonary endothelial injury.View full abstractDownload PDF (460K) -
TAKESHI YOSHIDA, TATSUO SUZUTANI, MASANOBU AZUMA1988 Volume 156 Issue 3 Pages 279-290
Published: 1988
Released on J-STAGE: August 31, 2006
JOURNAL FREE ACCESSThe appearance of drug resistant strains of herpes simplex virus type 1 (HSV-1) against 9-β-D-arabinofuranosyladenine (araA), in comparison with 5-iodo-2'-deoxyuridine (IUdR) and 9-(2-hydroxyethoxymethyl)guanine (acycloguanosine, ACG), has been investigated in green monkey kidney cell cultures (Vero) and human embryo lung cell cultures (HEL). Growth curves of HSV-1 in Vero cells and HEL cells in the presence or absence of 20 μg/ml of araA showed that not only the viruses produced by these cells in the presence of araA but also the viruses produced in the absence of araA were resistant to the same concentration of araA. However, both viruses were unable to grow in the presence of a combination of 20 μg/ml of araA and 3 μg/ml of erythro-9-(2-hydroxy-3-nonyl)adenine (EHNA) which is an inhibitor of adenosine deaminase. On the other hand, the viruses produced only in the presence of IUdR or ACG were resistant to each drug. All virus clones obtained from five serial clonings in the presence of araA alone or araA and EHNA in combination were not resistant to araA. These results show that the strain of HSV-1 resistant to araA is an apparently resistant strain, and a truly resistant strain to araA may not be established as easily as the truly resistant strains to IUdR and ACG.View full abstractDownload PDF (761K) -
HIROAKI SAKUMA, SADAO TAKASE, YASUJI MIZUNO, KAZUMINE TERAMURA, KUNIHI ...1988 Volume 156 Issue 3 Pages 291-298
Published: 1988
Released on J-STAGE: August 31, 2006
JOURNAL FREE ACCESSWe studied the function of hypothalamo-pituitary dopaminergic system in 15 myotonic dystrophy (MyD) patients whose growth hormone (GH) responses to insulin or arginine had been normal. We obtained the following findings : (1) basal levels of plasma GH and prolactin (PRL) were normal, although the latter levels were slightly lower than controls, (2) both GH and PRL responses to L-dopa or bromocriptine were significantly blunted compared with controls, (3) PRL response to sulpiride was also significantly low compared with controls. These results indicate that hypothalamic dopaminergic neuron and its postsynaptic dopamine receptors relating to GH secretion might be impaired. It was also suggested that the dopamine receptors of pituitary PRL cells might be impaired and the PRL reserve of pituitary cells might be decreased in some case.View full abstractDownload PDF (394K) -
HIROYUKI SHIMIZU, TOMOKO SAITO, SHIGERU HISAMICHI1988 Volume 156 Issue 3 Pages 299-302
Published: 1988
Released on J-STAGE: August 31, 2006
JOURNAL FREE ACCESSTo know the differences in utilization of medical care and medical costs among children and nonsmoking women depending on the states of smoking of other household members, the records of a health survey conducted in a town of Miyagi in 1987 were linked to the medical insurance records. The rates of medical care use and medical costs among nonsmoking women in nonsmoking households were almost the same as those in smoking households. Children in smoking households had medical care more often than those in nonsmoking households (74.1% vs. 56.4%) and the difference in the medical costs was also observed (¥33, 713 vs. ¥26, 558). The costs were almost correlated with the number of cigarettes smoked in the home.View full abstractDownload PDF (286K) -
YASUSHI TOMITA, KAZUHISA MAEDA, HACHIRO TAGAMI1988 Volume 156 Issue 3 Pages 303-304
Published: 1988
Released on J-STAGE: August 31, 2006
JOURNAL FREE ACCESSNormal human epidermal melanocytes became swollen and more dendritic with an increase in the amount of immunoreactive tyrosinase when they were cultured for 2 days with each one of leukotriene (LT) C4, LTD4 and TXB2. Their effects were stronger than that of prostaglandin E2, about which we have previously reported. From these data we suggest that arachidonate-derived chemical mediators, especially LTC4, LTD4 and TXB2 may be responsible for the induction of postinflammatory hyperpigmentation of the skin.View full abstractDownload PDF (140K)
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