Nuclear Deformity of Hepatocytes in Acute Viral Hepatitis

TOMOYUKI MASUDA; RYOICHI SATODATE; KAZUYUKI SUZUKI; SHUNICHI SATO

doi:10.1620/tjem.156.375

TOMOYUKI MASUDA, RYOICHI SATODATE, KAZUYUKI SUZUKI, SHUNICHI SATO

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Keywords: acute viral hepatitis, morphometry, image analysis, nuclear deformity

JOURNAL FREE ACCESS

1988 Volume 156 Issue 4 Pages 375-379

DOI https://doi.org/10.1620/tjem.156.375

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Published: 1988 Received: August 23, 1988 Available on J-STAGE: August 31, 2006 Accepted: October 28, 1988 Advance online publication: - Revised: -
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Date of correction: August 31, 2006 Reason for correction: - Correction: ABSTRACT Details: Wrong : MASUDA, T., SATODATE, R., SUZUKI, K. and SATO, S. Nuclear Deformity of Hepatocytes in Acute Viral Hepatitis. Tohoku J. exp. Med., 1988, 156 (4), 375-379 -Nuclear deformity of hepatocytes was measured using two parameters, the form factor and the axial ratio, in liver biopsy specimens from 29 patients with acute viral hepatitis (AVH). Another 13 patients with chronic persistent hepatitis (CPH) were added as control. Nuclear deformity of hepatocytes was morphometrically confirmed to increase in AVH compared to that in CPH. This was related to the regeneration of hepatocytes.
Right : Nuclear deformity of hepatocytes was measured using two parameters, the form factor and the axial ratio, in liver biopsy specimens from 29 patients with acute viral hepatitis (AVH). Another 13 patients with chronic persistent hepatitis (CPH) were added as control. Nuclear deformity of hepatocytes was morphometrically confirmed to increase in AVH compared to that in CPH. This was related to the regeneration of hepatocytes.

Date of correction: August 31, 2006 Reason for correction: - Correction: CITATION Details: Wrong : 1) de Groote, J., Desmet, V.J., Gedigk, P., Korb, G., Popper, H., Poulsen, H., Scheuer, P. J., Schmid, M., Thaler, H., Uehlinger, E. & Wepler, W. (1968) A classification of chronic hepatitis. Lancet, 2, 626-628.
2) Gschwind, R., Umbricht, C.B., Torhorst, J. & Oberholzer, M. (1986) Evaluation of shape descriptors for the morphometric analysis of cell nuclei. Path. Res. Pract., 181, 213-222.
3) Henmi, A., Uchida, T. & Shikata, T. (1985) Karyometric analysis of liver cell dysplasia and hepatocellular carcinoma: Evidence against precancerous nature of liver cell dysplasia. Cancer, 55, 2594-2599.
4) Joyce-Loebl (1985) Image processing. In: Image Analysis: Principles and Practice, Joyce Loebl, Gateshead, pp. 84-122.
5) Masuda, T., Madarame, T., Abe, K., Suzuki, A., Sato, S., Iwasaki, T. &; Satodate, R. (1988) Karyometric study of anisokaryosis of hepatocytes in acute viral hepatitis. In: Viral Hepatitis and Liver Disease, edited by A.J. Zuckerman, Alan R. Liss Inc., New York, pp. 190-191.
6) Payne, C.M., Grogan, T.M., Cromey, D.W., Bjore, C.G., Jr. & Kerrigan, D.P. (1987) An ultrastructural morphometric and immunophenotypic evaluation of Burkitt's and Burkitt's-like lymphomas. Lab. Invest., 57, 200-218.
7) Ranek, L., Jensen, S.T. & Keiding, N. (1975) Karyometry of liver biopsies in virus hepatitis. Acta path. microbiol. stand., A83, 477-486.
8) Roholm, K. & Iversen, P. (1939) Changes in the liver in acute epidemic hepatitis (catarrhal jaundice) based on 38 aspiration biopsies. Acta path. microbiol. scand., 16, 427-442.
9) Tauchi, H. & Sato, T. (1962) Some micromeasuring studies of hepatic cells in senility. J. Geront., 17, 254-259.
10) Watanabe, S., Okita, K., Harada, T., Kodama, T., Numa, Y., Takemoto, T. & Takahashi, T. (1983) Morphologic studies of the liver cell dysplasia. Cancer, 51, 2197-2205.

Right : 1) de Groote, J., Desmet, V. J., Gedigk, P., Korb, G., Popper, H., Poulsen, H., Scheuer, P. J., Schmid, M., Thaler, H., Uehlinger, E. & Wepler, W. (1968) A classification of chronic hepatitis. Lancet, 2, 626-628.
2) Gschwind, R., Umbricht, C. B., Torhorst, J. & Oberholzer, M. (1986) Evaluation of shape descriptors for the morphometric analysis of cell nuclei. Path. Res. Pract., 181, 213-222.
3) Henmi, A., Uchida, T. & Shikata, T. (1985) Karyometric analysis of liver cell dysplasia and hepatocellular carcinoma: Evidence against precancerous nature of liver cell dysplasia. Cancer, 55, 2594-2599.
4) Joyce-Loebl (1985) Image processing. In: Image Analysis: Principles and Practice, Joyce Loebl, Gateshead, pp. 84-122.
5) Masuda, T., Madarame, T., Abe, K., Suzuki, A., Sato, S., Iwasaki, T. & Satodate, R. (1988) Karyometric study of anisokaryosis of hepatocytes in acute viral hepatitis. In: Viral Hepatitis and Liver Disease, edited by A. J. Zuckerman, Alan R. Liss Inc., New York, pp. 190-191.
6) Payne, C. M., Grogan, T. M., Cromey, D. W., Bjore, C. G., Jr. & Kerrigan, D. P. (1987) An ultrastructural morphometric and immunophenotypic evaluation of Burkitt's and Burkitt's-like lymphomas. Lab. Invest., 57, 200-218.
7) Ranek, L., Jensen, S. T. & Keiding, N. (1975) Karyometry of liver biopsies in virus hepatitis. Acta path. microbiol. scand., A83, 477-486.
8) Roholm, K. & Iversen, P. (1939) Changes in the liver in acute epidemic hepatitis (catarrhal jaundice) based on 38 aspiration biopsies. Acta path. microbiol. scand., 16, 427-442.
9) Tauchi, H. & Sato, T. (1962) Some micromeasuring studies of hepatic cells in senility. J. Geront., 17, 254-259.
10) Watanabe, S., Okita, K., Harada, T., Kodama, T., Numa, Y., Takemoto, T. & Takahashi, T. (1983) Morphologic studies of the liver cell dysplasia. Cancer, 51, 2197-2205.

Date of correction: August 31, 2006 Reason for correction: - Correction: PDF FILE Details: -

Date of correction: August 31, 2006 Reason for correction: - Correction: AFFILIATION Details: Wrong :
1) Department of Pathology, Iwate Medical University
2) Department of Internal Medicine, School of Medicine, Iwate Medical University

Right :
1) Department of Pathology, School of Medicine, Iwate Medical University
2) Department of Internal Medicine, School of Medicine, Iwate Medical University

Date of correction: August 31, 2006 Reason for correction: - Correction: PDF FILE Details: -

Abstract

Nuclear deformity of hepatocytes was measured using two parameters, the form factor and the axial ratio, in liver biopsy specimens from 29 patients with acute viral hepatitis (AVH). Another 13 patients with chronic persistent hepatitis (CPH) were added as control. Nuclear deformity of hepatocytes was morphometrically confirmed to increase in AVH compared to that in CPH. This was related to the regeneration of hepatocytes.

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