Abstract
FUNAUCHI, M., SUGISHIMA, H., HIGASHIKAWA, M., IKEDA, K., MINODA, M. and HORIUCHI, A. Mixed Lymphocyte Reaction in Interferon-γ Treated (NZB× NZW)F1 Mice. Tohoku J. Exp. Med., 1989, 158 (2), 155-161-Mouse interferon-γ was administered to (NZB×NZW)F1 mice, which develop a disease like human systemic lupus erythematosus. Class II antigens on adherent spleen cells and their activity to stimulate allogeneic T lymphocyte in mixed lymphocyte reaction were observed as well as the changes of the clinical findings of the mice. In interferon-γ treated mice, as compared to control mice, the positive rate for class II antigen on adherent spleen cells was increased, and the mixed lymphocyte reaction using the cells of interferon-γ treated mice as stimulator cells was enhanced. These findings suggest that the enhancement of antigen presenting activity of adherent spleen cells to T lymphocytes might be associated in the exacerbation of the disease in interferon-γ treated (NZB×NZW)F1 mice.
