All issues
Volume 158 (1989)
- Issue 4 Pages 265-
- Issue 3 Pages 179-
- Issue 2 Pages 107-
- Issue 1 Pages 1-
Volume 158, Issue 2
Displaying 1-8 of 8 articles from this issue
- |<
- <
- 1
- >
- >|
-
JIN ISHIZUKA, JUNKO NAKAGAWA, CHIZUKO YANAIHARA, NOBORU YANAIHARA, YUK ...1989 Volume 158 Issue 2 Pages 107-117
Published: 1989
Released on J-STAGE: August 31, 2006
JOURNAL FREE ACCESSISHIZUKA, J., NAKAGAWA, J., YANAIHARA, C., YANAIHARA, N., CHIBA, Y., IMAIZUMI, H., KONNO, K., KOIZUMI, M. and TOYOTA, T. Establishment of the Specific Radioimmunoassay for Serum Thymic Factor (STF). Tohoku J. Exp. Med., 1989, 158 (2), 107-117-Serum thymic factor is a humoral factor involved in the differentiation of T cells. In the present study, a radioimmunoassay system for STF was established using a specific antiserum and an iodinated synthetic STF as a tracer. Serum levels of STF-like immunoreactivities were around 30pg/ml in human, but in contrast to previous reports serum STF levels did not show age-dependent decreases. STF-like immunoreactivities of the thymic gland were lower than those of the liver and kidney in rats. The livers of human and pig contained high STF-like immunoreactivities. The rat thymic gland extract showed three peaks of STF-like immunoreactivity by gel filtration of Sephadex G-25 which corresponded to the eluted position of authentic STF, a larger molecular size, and a smaller molecular size of STF, respectively, while the rat liver extract showed two peaks corresponding to the void volume fraction and to the position of authentic STF, respectively. When this void volume fraction was digested by trypsin, three peaks which corresponded to authentic STF, a larger molecular size, and a smaller molecular size of STF were observed. Present studies suggest that serum thymic factor is produced as a larger STF molecule in the liver and kidney.View full abstractDownload PDF (852K) -
TOYOHARU ISAWA, TAKEO TESHIMA, TOMIO HIRANO, YOSHIKI ANAZAWA, MAKOTO M ...1989 Volume 158 Issue 2 Pages 119-131
Published: 1989
Released on J-STAGE: August 31, 2006
JOURNAL FREE ACCESSISAWA, T., TESHIMA, T., HIRANO, T., ANAZAWA, Y., MIKI, M., KONNO, K. and MOTOMIYA, M. Normal Values for Quantitative Parameters for Evaluation of Mucociliary Clearance in Lungs. Tohoku J. Exp. Med., 1989, 158 (2), 119-131 -Twenty-eight normal male subjects (13 nonsmokers and 15 smokers, 25 to 76 years of age) inhaled ultrasonically generated 99mTc-tagged human serum albumin aerosol (mass median diameter: 1.93μm with geometric standard deviation of 1.52) and radioactivity from the thorax was measured continuously from anteriorly in 10sec frame mode for 90 to 120min to evaluate mucociliary clearance function in the lungs. Normal values for lung retention ratio (LRR), airway deposition ratio (ADR), airway retention ratio (ARR), airway clearance efficiency (ACE), alveolar deposition ratio (ALDR), and disappearance rate of radioactivity from the ciliated airways (DR) were presented. ALDR was significantly larger in nonsmokers than in smokers. LRR and ARR were significantly smaller and ACE, significantly larger in smokers at any time intervals than in nonsmokers, while ADR and DR were larger in smokers only in the initial 30min following radioaerosol inhalation was completed. Thereafter there was little difference in ADR and DR between normal smokers and nonsmokers.View full abstractDownload PDF (1200K) -
TOSHIFUMI KANAIZUMI, HIROSHIGE NAKANO, TAISUKE MATSUI, HIDENORI TATSUM ...1989 Volume 158 Issue 2 Pages 133-140
Published: 1989
Released on J-STAGE: August 31, 2006
JOURNAL FREE ACCESSKANAIZUMI, T., NAKANO, H., MATSUI, T., TATSUMI, H., ISHIKAWA, H., KURAMOTO, H., SHIMIZU, R, and SHIRATORI, T. Gastric Emptying in Patients with Gastric and Duodenal Ulcer. Tohoku J. Exp. Med., 1989, 158 (2), 133-140-Gastric emptying was measured in patients with proximal gastric, distal gastric and duodenal ulcers using a radioisotopic method. Gastric emptying was rapid in patients with proximal gastric ulcer, and was considered to be due to accerelated proximal evacuation. However, emptying was delayed in patients with distal gastric ulcer, and was considered to be due to reduced emptying in the antrum. On the other hand, rapid emptying seen in duodenal ulcer patients was considered to be due to accerelated emptying in both the proximal stomach and the antrum. Gastric emptying in the healing stage was closer to that in healthy subjects than in patients with active-stage ulcer.View full abstractDownload PDF (628K) -
CHANG-LIANG CHAO, GEN TAMURA, SUETSUGU MUE, TAMOTSU TAKISHIMA1989 Volume 158 Issue 2 Pages 141-148
Published: 1989
Released on J-STAGE: August 31, 2006
JOURNAL FREE ACCESSCHAO, C.L., TAMURA, G., MUE, S, and TAKISHIMA, T. A Production of Dermatophagoides Farinae Allergen-Specific IgE and Ig(G+M) Antibodies by Cultured Peripheral Blood Mononuclear Cells of Patients with Extrinsic Bronchial Asthma. Tohoku J. Exp. Med., 1989, 158 (2), 141-148-Using a modified reverse hemolytic plaque assay, we measured in vitro production of Dermatophagoides farinae allergen-specific IgE and Ig(G+M) antibodies by peripheral blood mononuclear cells in 19 patients with extrinsic bronchial asthma. Circulating the allergen-specific IgE was estimated by means of the Phadebas® radioallergosorbent test system. We found a significant difference in the production of the allergen-specific IgE antibody by the cells between asthmatic patients with positive and negative circulating the allergen-specific IgE.View full abstractDownload PDF (820K) -
TOYOHARU ISAWA, REIKO ONO, MASAKICHI MOTOMIYA, NOBUAKI TAMAHASHI1989 Volume 158 Issue 2 Pages 149-154
Published: 1989
Released on J-STAGE: August 31, 2006
JOURNAL FREE ACCESSISAWA, T., ONO, R., MOTOMIYA, M. and TAMAHASHI, N. Fatal Acute Interstitial Pneumonia Induced by Low-Dose Doxorubicin and Vindesine. Tohoku J. Exp. Med., 1989, 158 (2), 149-154-A 53-year-old female smoker with small cell carcinoma of the lung with cerebral metastases was initially treated with whole brain radiation with favorable responses. She developed fulminant and fatal interstitial pneumonia following administration of 30mg of doxorubicin and 6mg of vindesine. Histopathology revealed that the interstitial pneumonia was compatible with a druginduced penumonia.View full abstractDownload PDF (3352K) -
MASANORI FUNAUCHI, HITOSHI SUGISHIMA, MITSUHIRO HIGASHIKAWA, KEIZOU IK ...1989 Volume 158 Issue 2 Pages 155-161
Published: 1989
Released on J-STAGE: August 31, 2006
JOURNAL FREE ACCESSFUNAUCHI, M., SUGISHIMA, H., HIGASHIKAWA, M., IKEDA, K., MINODA, M. and HORIUCHI, A. Mixed Lymphocyte Reaction in Interferon-γ Treated (NZB× NZW)F1 Mice. Tohoku J. Exp. Med., 1989, 158 (2), 155-161-Mouse interferon-γ was administered to (NZB×NZW)F1 mice, which develop a disease like human systemic lupus erythematosus. Class II antigens on adherent spleen cells and their activity to stimulate allogeneic T lymphocyte in mixed lymphocyte reaction were observed as well as the changes of the clinical findings of the mice. In interferon-γ treated mice, as compared to control mice, the positive rate for class II antigen on adherent spleen cells was increased, and the mixed lymphocyte reaction using the cells of interferon-γ treated mice as stimulator cells was enhanced. These findings suggest that the enhancement of antigen presenting activity of adherent spleen cells to T lymphocytes might be associated in the exacerbation of the disease in interferon-γ treated (NZB×NZW)F1 mice.View full abstractDownload PDF (637K) -
MINORU NIHEI, YUTAKA IMAI, KEISHI ABE, SHUICHI SASAKI, NAOYOSHI MINAMI ...1989 Volume 158 Issue 2 Pages 163-169
Published: 1989
Released on J-STAGE: August 31, 2006
JOURNAL FREE ACCESSNIHEI, M., IMAI, Y., ABE, K., SASAKI, S., MINAMI, N., MUNAKATA, M., SAKUMA, H., HASHIMOTO, J., SEKINO, H. and YOSHINAGA, K. Similarity in Amplitude of the Nocturnal Fall in Blood Pressure in Old and Young Patients with Essential Hypertension. Tohoku J. Exp. Med., 1989, 158 (2), 163-169-The influence of age on the nocturnal fall in blood pressure (BP) was examined in essential hypertensive patients as well as normal subjects. BP was monitored every 5min for 24hr by means of a finger volume oscillometric device. Average daytime BP was similar in the 3 age groups [young: <40 (years), n=49, average daytime systolic BP (ASBP)=132±20mmHg, average daytime diastolic BP (ADBP)=82±17mmHg; adult: 40≤ <60, n=110, ASBP=127±19mmHg, ADBP=86± 13mmHg; old: 60≤, n=33, ASBP=131±17mmHg. ADBP=83±11, mean± S.D.]. The nocturnal fall in BP was observed in all age groups and its amplitude(ΔBP=average daytime BP-average nighttime BP) in the old patients (ΔSBP=13±11mmHg, ΔDBP=10+8mmHg) was similar to that in the young patients (ΔSBP=11±8mmHg, ΔDBP=10±8mmHg). The result suggests that information on the nocturnal behavior of BP is valuable in treating aged essential hypertensives to prevent cerebral and/or myocardial ischemia during sleep.View full abstractDownload PDF (666K) -
KIYOAKI OUCHI, SHUJI MATSUBARA, KENJI FUKUHARA, KENJI FUKUHARA, SEIKI ...1989 Volume 158 Issue 2 Pages 171-178
Published: 1989
Released on J-STAGE: August 31, 2006
JOURNAL FREE ACCESSOUCHI, K., MATSUBARA, S., FUKUHARA, K. and MATSUNO, S. Plasma Amino Acid Abnormalities in Liver Disease: Comparative Analysis of Idiopathic Portal Hypertension, Extrahepatic Portal Occlusion and Liver Cirrhosis. Tohoku J. Exp. Med., 1989, 158 (2), 171-178-To clarify the clinical significance of specific plasma amino acid abnormalities occurring in liver disorders with portal-systemic shunting, plasma amino acids and insulin levels were measured in idiopathic portal hypertension (IPH), extrahepatic portal occulusion (EHPO), and liver cirrhosis (LC). Three branched chain amino acids (BCAA: valine+leucine+isoleucine) were decreased in all three diseases in comparison with controls. Since plasma insulin measured during oral glucose tolerance tests did not specifically rise in LC, reduction of BCAA is not merely ascribed to hyperinsulinemia. Either portal-systemic shunting or some extent of liver damage may contribute to a fall in BCAA. Two aromatic amino acids (AAA: phenylalanine+tyrosine), which were within the normal range in EHPO and IPH, showed a marked increase in LC. Thus, changes of AAA probably mainly reflect the severity of the liver disease. The molar ratio of BCAA/AAA (MR) significantly correlated with ICG k, ICG R15, PT and the sum of blood ammonia in an oral ammonia tolerance test which may reflect the degree of hepatic disorder. MR diminished in the following decreasing order: controls, EHPO, IPH and LC.View full abstractDownload PDF (741K)
- |<
- <
- 1
- >
- >|