Induction of Recurrent Glomerulitis with Accentuated Glomerular Lobulation by Intermittent Repetition of Unilateral Masugi Nephritis

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SHOJI, S. and FUJIMOTO, T. Induction of Recurrent Glomerulitis with Accentuated Glomerular Lobulation by Intermittent Repetition of Unilateral Masugi Nephritis. Tohoku J. Exp. Med., 1990, 160 (1), 19-35-In order to induce a glomerulitis with lobular features, antirabbit renal glomerular basement membrane hen serum was intravenously injected into rabbits repeatedly at intervals of 3 weeks, during the course of clamping of contralateral renal arteries for 20min. The first injection induced disorganization of the glomerular architecture accompanied by proliferation of local fixed cells and following crowding of the proliferated cells towards the axis of the loops and peripheral recanalization which brought about a lobular appearance of glomerulus. And the repeated injections induced repetition of such processes, resulting in accentuation or exaggeration of the lobular features of the glomeruli. The glomerular lesions presented here resembled closely to those of human lobular glomerulonephritis. Accordingly, the results of this study will offer some clue to understanding of the genesis of the human glomerular disease.