Abstract
UENO, Y., SUZUKI, H., KOBAYASHI, K., MIURA, M. and TOYATA, T. Production of Tumor Necrosis Factor α and Interleukin 1β by Peripheral Blood Mononuclear Cells from Chronic Hepatitis Type C Patients during Interferon Therapy. Tohoku J. Exp. Med., 1990, 161 (2), 157-158-To elucidate the role of tumor necrosis factor α (TNF-α) and interleukin 1β (IL-1β) in chronic hepatitis type C (CH(C)), TNF α and IL-1β released from peripheral blood mononuclear cells were measured in 6 CH(C) patients before and during interferon therapy. During the therapy, TNF-α levels were significantly high in two patients whose serum ALT levels turned normal, while IL-1β levels did not show significant change. These results suggest that TNF-α takes part in improvement of CH(C).
