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Volume 161 (1990)
- Issue 4 Pages 261-
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- Issue 2 Pages 73-
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Volume 161, Issue 2
Displaying 1-10 of 10 articles from this issue
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SHINOBU SATO, SHUICHI KATO, HIHUMI TAKAHASHI, KEIJI TAKAHASHI, SHOJI Y ...1990 Volume 161 Issue 2 Pages 73-83
Published: 1990
Released on J-STAGE: August 31, 2006
JOURNAL FREE ACCESSSATO, S., KATO, S., TAKAHASHI, H., TAKAHASHI, K. and YASUI, S. Pulmonary Vascular Response to Acetylcholine in Isolated Rat Lungs Treated with Intratracheal Bleomycin. Tohoku J. Exp. Med., 1990, 161 (2), 73-83-We tested the hypothesis that during alveolar hypoxia the vasodilator response to acetylcholine (ACh) is impaired in lungs injured by intratracheal bleomycin. Isolated rat lungs were ventilated with normoxic (21% O2) or hypoxic (2% O2) gas and perfused with homologous blood. The effect of ACh on pulmonary vascular resistance was estimated during ongoing hypoxic pulmonary vasoconstriction (HPVC) after the temporal pattern of HPVC was established. The magnitude of the decrease in pulmonary vascular resistance was significantly smaller in the bleomycin-treated group (group B, n=7) than in the saline-treated group (group S, n=7) (p<0.05). The magnitude of HPVC itself did not differ between groups. The pulmonary vascular reactivities to angiotensin II and KCl were similar in the two groups (group S, n=4, group B, n=5). At any given transpulmonary pressure the lung volumes of group B (n=5) were significantly smaller than those of group S (n=4) (p<0.01). We conclude that vascular dilation in response to ACh during ongoing HPVC was impaired in bleomycin-injured rat lungs.View full abstractDownload PDF (1096K) -
MORIO AIHARA, KEIKO SASAKI, YUTAKA YOSHIDA1990 Volume 161 Issue 2 Pages 85-90
Published: 1990
Released on J-STAGE: August 31, 2006
JOURNAL FREE ACCESSAIHARA, M., SASAKI, K. and YOSHIDA, Y. Ubenimex Treatment in Congenital Cyclic Neutropenia. Tohoku J. Exp. Med., 1990, 161 (2), 85-90-A female patient with congenital cyclic neutropenia was presented. The cycle of neutropenia and the duration of neutropenia of less than 500/μl was approximately three weeks and two weeks, respectively. There were also oscillations of monocytes and eosinophils with the peak level at the neutropenic phase. The severity and incidence of infections tended to diminish when the patient was pregnant. There were no abnormalities of lymphocyte subpopulations including CD4, CD8, CD4/CD8 ratio, and CD16. Administration of the immunomodulator ubenimex (Bestatin®), 30mg/day, reduced the severity of infections during the neutropenic periods, although the cyclic of neutropenia was not altered.View full abstractDownload PDF (596K) -
HIDEAKI KIKUCHI, TAKAO SEKIYA, SUSUMU NISHIMURA, MINRO WATANABE1990 Volume 161 Issue 2 Pages 91-99
Published: 1990
Released on J-STAGE: August 31, 2006
JOURNAL FREE ACCESSKIKUCHI, H., SEKIYA, T., NISHIMURA, S. and WATANABE, M. Repetitive Sequences in the Rat Genome that Have Cleavage Sites for the Restriction Endonuclease Taq I. Tohoku J. Exp. Med., 1990, 161 (2), 91-99-A cleavage of rat DNA with restriction endonuclease Tag I produced at least 8 discrete bands. One of the bands, 0.29 kilobase pairs (kb) long, was isolated and cloned in plasmid. The hybridization of this fragment to genomic DNA digested with Taq I showed 1.6kb, 1.2kb and 0.29kb band in a smear hybridization signal. A repetition of the DNA sequence of this fragment was about 12, 500 copies haploid genome of both Buffalo and Sprague-Dawley rats by the Cot-hybridization analysis. Four independent clones of 0.29kb Taq I fragment share high homology (97%).View full abstractDownload PDF (1529K) -
SHINOBU SATO, SHUICHI KATO, HIHUMI TAKAHASHI, YASUSI ARISAKA, KEIJI TA ...1990 Volume 161 Issue 2 Pages 101-110
Published: 1990
Released on J-STAGE: August 31, 2006
JOURNAL FREE ACCESSSATO, S., KATO, S., TAKAHASHI, H., ARISAKA, Y. and TAKAHASHI, K. Dose Dependency of Intratracheal Elastase-Induced Changes in Pressure Volume Curve and Morphometry in Rat Lungs. Tohoku J. Exp. Med., 1990, 161 (2), 101-110-We studied the dose-dependency of the lung pressure-volume curve (n=37) and morphometry (n=30) with intratracheally administered elastase. Four weeks after elastase was instilled at dosages of 20 (EL-20), 40, 80, and 100U/100 g wt., chord compliance between 50 and 70% of total lung capacity (TLC) (C50-70) and that between 80 and 100% TLC (C80-100) Were measured. After a significant initial reduction, the weight of the EL-80 group recovered to the control level, whereas the weight curve of the EL-100 significantly decreased below that of the EL-80. Lung volumes of all the elastase-treated groups were significantly larger than those of control. Air-filled lung volumes monotonously increased when the elastase dose was increased from 20 to 80U/100g wt. In contrast lung volume of the EL-100 was significantly lower than that of the EL-80. On the other hand, liquid-filled lung volumes monotonously increased from 20 to 100U/100g wt. C80-100 was significantly smaller in the EL-100 than in the EL-80. The mean linear intercept increased and alveolar surface area decreased monotonously over the dose range tested. We conclude that there is a critical dose of elastase below which lung volume is increased and above which the increase is suppressed when elastase is administered intratracheally to Wistar rats.View full abstractDownload PDF (1025K) -
HIROSHI TAKAHASHI, SHUICHI FUJITA, NOBUO TSUDA, FUMIAKI TEZUKA, HARUO ...1990 Volume 161 Issue 2 Pages 111-128
Published: 1990
Released on J-STAGE: August 31, 2006
JOURNAL FREE ACCESSTAKAHASHI, H., FUJITA, S., TSUDA, N., TEZUKA, F. and OKABE, H. Intraoral Minor Salivary Gland Tumors: A Demographic and Histologic Study of 200 Cases. Tohoku J. Exp. Med., 1990, 161 (2), 111-128-In a demographic and histologic study of 200 intraoral minor salivary gland tumors seen in Japan (Nagasaki and Miyagi prefectures), 127 cases (63.5%) were classified as benign, comprising 124 pleomorphic adenomas and 3 monomorphic adenomas. The other 73 cases (36.5%) were malignant tumors, represented by 33 adenoid cystic carcinomas, 16 mucoepidermoid carcinomas, 10 carcinoma in pleomorphic adenomas, 6 acinic cell carcinomas, 5 adenocarcinomas, one polymorphous low-grade adenocarcinoma, one undifferentiated carcinoma and one clear cell carcinoma. There was an overall female preponderance (1.78/1). The mean age for females was 47.2 years and for males was 50.6 years. The mean age for patients with malignant tumors was 10 years greater than for patients with benign tumors and as statistically significant. The palate was the most common site for intraoral minor salivary gland tumors followed by the lip and buccal mucosa. These three sites accounted for 83% of all cases. Tumors arising in these three sites were predominantly benign. In contrast, those located in the gingiva, floor of the mouth and tongue were predominantly malignant. The results of this study were compared with other recent studies.View full abstractDownload PDF (4569K) -
TAKASHI OGASAWARA, KYOJI TASAKI1990 Volume 161 Issue 2 Pages 129-135
Published: 1990
Released on J-STAGE: August 31, 2006
JOURNAL FREE ACCESSOGASAWARA, T. and TASAKI, K. Bimodality in the Nocturnal Behavior of the Giant Land Snail, Achatina fulica. Tohoku J. Exp. Med., 1990, 161 (2), 129-135 -Entrainment and phase advance of the circadian locomotor rhythms in the giant land snail, Achatina fulica, were examined by a running wheel method. The mean activity patterns in three light-dark (LD) cycles (LD 14:10, LD12:12, LD 10:14) were characterized by bimodal peaks, namely an initial major peak 1-2hr after the onset of darkness and a later peak after nearly 6hr. The activity rhythms were able to follow a 6hr phase advance shift of the LD 14:10 cycle with transients, accompanied by shortening or splitting of the activity time. When splitting occurred, the initial component showed phase advancement in the dark and phased to lights-off whereas the later one phased to lights-on, with post-dawn activity being suppressed by light. These results suggest the presence of multioscillator circadian organization which shows monophasic or biphasic entrainment under the LD cycles.View full abstractDownload PDF (576K) -
KAMEEL A. HUSSEIN, BATOOL Al-IBRAHIM1990 Volume 161 Issue 2 Pages 137-151
Published: 1990
Released on J-STAGE: August 31, 2006
JOURNAL FREE ACCESSHUSSEIN, K.A. and Al-IBRAHIM, B. The Determination of Plasma Intrinsic Coagulant Activity. Tohoku J. Exp. Med., 1990, 161 (2), 137-151-The increase in absorbance was traced during the coagulation of citrated plasma, while in contact with a plastic cuvette surface. The tracings gave rise to coagulation curves, which provided four values. The coagulation curve values were found to change by time due to contact with the surface of the tube containing the plasma. The rate of change was used to determine the intrinsic coagulant activity, in response to a weak activating surface. The value of the determination as a means for detecting hypercoagulability is discussed. The method was also used to study the effect of different factors affecting intrinsic plasma coagulant activity as; the urface of different tubes, plasma concentration, temperature of the tube containing the plasma and platelet concentration.View full abstractDownload PDF (1185K) -
SHINICHI OKUYAMA, HITOSHI MISHINA, TOORU NUNOKAWA1990 Volume 161 Issue 2 Pages 153-154
Published: 1990
Released on J-STAGE: August 31, 2006
JOURNAL FREE ACCESSOKUYAMA, S., MISHINA, H. and NUNOKAWA, T. Medroxyprogesterone Acetate for Lung Cancer. Tohoku J. Exp. Med., 1990, 161 (2), 153-154-A 70-year-old man having severe ischemic heart diseases developed bilateral, duplicate lung cancer of large cell and squamous cell types. Chemoimmunotherapy consisting of carmofur, picibanil inhalation, i.m. sizofilan, and peroral bestatin was started, and 3 months later, peroral mdroxyprogesterone acetate was added. The tumor regressed, and the patient survived more than 34 months. This type of non-aggressive regimen may thus be useful for tumors other than adenocarcinomas, too.View full abstractDownload PDF (980K) -
SHINICHI OKUYAMA, HITOSHI MISHINA, KENICHI FUNAKI, TOSHIHIKO MORI1990 Volume 161 Issue 2 Pages 155-156
Published: 1990
Released on J-STAGE: August 31, 2006
JOURNAL FREE ACCESSOKUYAMA, S., MISHINA, H., FUNAKI, K. and MORI, T. Reinforcing Radiotherapy of Gallbladder Cancer with Aclarubicin and Neocarzinostatin. Tohoku J. Exp. Med., 1990, 161 (2), 155-156-Cancer of the gallbladder is radioresistant. When a 59-year-old woman was found to have an inoperable cancer of the gallbladder, she was subjected to radiotherapy combined with aclarubicin and neocarzinostatin. Therapeutic effectiveness was confirmed at autopsy as she later succumbed to uterine cervical cancer. Thus, the present radiochemotherapeutic regimen would probably provide a means of overcoming those radioresistant inoperable malignancies.View full abstractDownload PDF (1851K) -
YOSHIYUKI UENO, HIROSHI SUZUKI, KOJU KOBAYASHI, MASAHITO MIURA, TAKAYO ...1990 Volume 161 Issue 2 Pages 157-158
Published: 1990
Released on J-STAGE: August 31, 2006
JOURNAL FREE ACCESSUENO, Y., SUZUKI, H., KOBAYASHI, K., MIURA, M. and TOYATA, T. Production of Tumor Necrosis Factor α and Interleukin 1β by Peripheral Blood Mononuclear Cells from Chronic Hepatitis Type C Patients during Interferon Therapy. Tohoku J. Exp. Med., 1990, 161 (2), 157-158-To elucidate the role of tumor necrosis factor α (TNF-α) and interleukin 1β (IL-1β) in chronic hepatitis type C (CH(C)), TNF α and IL-1β released from peripheral blood mononuclear cells were measured in 6 CH(C) patients before and during interferon therapy. During the therapy, TNF-α levels were significantly high in two patients whose serum ALT levels turned normal, while IL-1β levels did not show significant change. These results suggest that TNF-α takes part in improvement of CH(C).View full abstractDownload PDF (156K)
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