Abstract
FURUHASHI, N., TSUJIEI, M., KIMURA, H., YAJIMA, A., KIMURA, C. and IDE, Y. Plasma Renin Activity, Angiotensin II, Prostacyclin and Thromboxane A2 Concentrations in 139 Preeclamptic Patients. Tohoku J. Exp. Med., 1990, 162 (3), 235 -241-Plasma renin activity, plasma concentratrions of angiotensin 11(AngII), stable metabolites (6-keto-prostaglandin F1α: 6-keto-PGF1α) of prostacyclin (PGI2) and a metabolite (thromboxane B2: TXB2) of thromboxane A2 (TXA2) were measured with radioimmunoassay(RIA) in 107 normal pregnancy (control) and 139 preeclamptic patients in 28-41 gestational weeks. PRA and 6-keto-PGF1α were significantly higher and AngII was slightly higher in preeclampsia than in control, and TXB2 was significantly lower in preeclampsia in control. The ratio of 6-keto-PGF1α/TXB2 was significantly lower in preeclampsia than in control. These data suggest that the changes in the renin-angiotensin system may not be primary alterations in preeclampsia. It can be speculated that in preeclampsia the changes in absolute concentrations of 6-keto-PGF1α and TXB2 are less important than the decrease in the ratio of the 6-keto-PGF1α/TXB2.
