抄録
FURUHASHI, N., TSUJIEI, M., KIMURA, H., YAJIMA, A., KIMURA, C. and IDE, Y. Plasma Renin Activity, Angiotensin II, Prostacyclin and Thromboxane A2 Concentrations in 139 Preeclamptic Patients. Tohoku J. Exp. Med., 1990, 162 (3), 235 -241-Plasma renin activity, plasma concentratrions of angiotensin 11(AngII), stable metabolites (6-keto-prostaglandin F1α: 6-keto-PGF1α) of prostacyclin (PGI2) and a metabolite (thromboxane B2: TXB2) of thromboxane A2 (TXA2) were measured with radioimmunoassay(RIA) in 107 normal pregnancy (control) and 139 preeclamptic patients in 28-41 gestational weeks. PRA and 6-keto-PGF1α were significantly higher and AngII was slightly higher in preeclampsia than in control, and TXB2 was significantly lower in preeclampsia in control. The ratio of 6-keto-PGF1α/TXB2 was significantly lower in preeclampsia than in control. These data suggest that the changes in the renin-angiotensin system may not be primary alterations in preeclampsia. It can be speculated that in preeclampsia the changes in absolute concentrations of 6-keto-PGF1α and TXB2 are less important than the decrease in the ratio of the 6-keto-PGF1α/TXB2.
