Abstract
CHIBA, S. and TSUKADA, M. Potentiation of Acetaldehyde-Induced Vasoconstrictions by Cocaine in Isolated and Perfused Arteries. Tohoku J. Exp. Med., 1991, 165 (1), 63-65-Vasoconstrictor responses to acetaldehyde (AA), norepinephrine (NE) and tyramine were investigated in isolated, perfused canine intermediate auricular (ear) arteries. Single injections of small doses of AA (1-3 μmol) induced a vasoconstriction in a dose-related manner and showed no tachyphylaxis. Cocaine significantly inhibited tyramine-induced vasoconstrictions, but NE- and AA-induced vasoconstrictions were rather significantly enhanced.
