Abstract
KONDO, S., TASHIMA, Y. and MORITA, T. Effect of Cimetidine on the Density of Adrenergic Alpha-1 and Alpha-2 Receptors in the Rat Whole Prostate. Tohoku J. Exp. Med., 1992, 167 (2), 163-166-In order to study the antiprostatic effect of cimetidine, we measured adrenergic α-1 and α-2 receptors of the whole prostate of cirmetidine-administered rats using radioligand binding techniques. Saturation e×periments using 3H-prazosin and 3H-yohimbine revealed that there were significant amounts of α-1 and α-2 receptors in the rat whole prostate. There were more α-1 receptors than α-2 receptors in both the control and treated groups. In the treated group, the density of α-1 receptors showed little change, while that of α-2 receptors showed a significant decrease in comparison to the control group without changes in KD values. These data suggest that cimetidine affects the prostatic alpha receptors and consequently decreases the density of adrenergic α-2 receptors in the prostate.
