Abstract
KONDO, S., KAGAYA, M., TASHIMA, Y. and MORITA, T. The Quantitative Difference in Adrenergic Alpha-1, Alpha-2 and Beta Receptors between the Prostatic and Epididymal Ends of Dog Vas Deferens. Tohoku J. Exp. Med., 1992, 167 (2), 167-169-In order to study the regional differences in the distribution of adrenergic receptors of the vas deferens, we measured the amounts of adrenergic α-1, α-2 and β receptors in prostatic, intermediate, and epididymal portions of the dog vas deferens using radioligand binding techniques. Saturation experiments with 3H-prazosin, 3H-yohimbine, and 3H-dihydroxyalprenolol demonstrated that there were significant amounts of adrenergic α-1, α-2, and β receptors, respectively, in these three portions. α-1 receptors existed most densely in the whole vas deferens. The prostatic portion was found to have the largest amounts of α-1 and α-2 receptors among three portions studied. β-Receptors were distributed most densely in the intermediate portion. α-1, α-2, and β adrenergic receptors show different distribution patterns throughout the whole length of vas deferens.
