Abstract
MIZOI, T., OHTANI, H., MATSUNO, S. and NAGURA, H. Immunohistochemical Identification of Transforming Growth Factor-β and Its Binding Protein in Human Gastrointestinal Carcinoma. Tohoku J. Exp. Med., 1992, 168 (2), 271-273-We attempted to clarify the tissue localization of TGF-β and latent TGF-β binding protein (LTBP) in human gastrointestinal carcinomas by immunohistochemistry. The immunoreactivity for TGF-β was observed in both carcinoma cells and stromal cells, particularly in diffuse-type gastric carcinoma. The immunoreactivity for LTBP was observed only in stromal cells. These results suggest that both carcinoma cells and stromal cells may produce TGF-β, and that only stromal cells may produce LTBP in gastrointestinal carcinoma.-TGF-β; latent TGF-β binding protein; gastrointestinal carcinoma; immunohistochemistry; immunoelectron microscopy
