Abstract
HASHIMOTO, Y., OSADA, S., OHNO, S. and KUROKI, T. A Ca2+-Independent Protein Kinase C, nPKCη: Its Structure, Distribution and Possible Function. Tohoku J. Exp. Med., 1992, 168 (2), 275-278-Protein kinase C consists of a protein family which can be classified into two major groups: Ca2+-dependent conventional protein kinase C and Ca2+-independent novel protein kinase C (nPKC). Among eight known members of protein kinase C family, we found that nPKCη (eta) isolated from cDNA library of mouse skin, is most abundant in epithelial tissues including skin and epithelia of digestive and respiratory tracts. These data suggest potential role of this isoform in growth, differentiation and carcinogenesis of epithelial tissues.-protein kinase C; tumor promotion; epithelial cells
