Effects of Massive Small Bowel Resection on Metabolism of Bile Acids and Vitamin D₃ and Gastrin Release in Dogs

Abstract

IMAMURA, M. and YAMAUCHI, H. Effects of Massive Small Bowel Resection on Metabolism of Bile Acids and Vitamin D3 and Gastrin Release in Dogs. Tohoku J. Exp. Med., 1992, 168 (3), - 515-528, The effects of ursodeoxycholic acid (UDCA) and 1α-hydroxyvitamin D3 on pathophysiological changes following massive resection of the distal small bowel (75%) were investigated by using adult beagle dogs. After surgery, body weight decreased, watery diarrhea occurred, and the transit time of the alimentary tract shortened. These undesirable consequences lessened markedly after oral administration of UDCA, though 1α- hydroxyvitamin D₃ was not effective. Plasma levels of both 25-hydroxyvitamin D₃ and 24, 25-dihydroxyvitamin D₃ decreased after surgery, while plasma 1α, 25-dihydroxyvitamin D₃ concentrations remained unchanged during the observation period of six months. Although fasting plasma concentrations of total bile acid were not reduced, the integrated response to a meal decreased significantly after surgery in spite of the administration of UDCA. The concentration of UDCA in the gallbladder bile increased markedly in dogs which received UDCA. Taurine-conjugated bile acids accounted for more than 90% of the gallbladder bile. Postprandial hypergastrinemia occurred following the massive small bowel resection in the control group and in the group which received 1α-hydroxyvitamin D₃ alone, while it did not occur in the group given UDCA together with 1α- hydroxyvitamin D₃. These results indicate that administration of UDCA after massive resection of the small intestine is effective in maintaining good nutritional state. - dog; massive small bowel resection; test meal; ursodeoxycholic acid; 1α-hydroxyvitamin D₃; gastrin