Abstract
HOSHI, K., HASHIMOTO, Y. and MATSUKAWA, S. Pharmacokinetics of Succinylcholine in Man. Tohoku J. Exp. Med., 1993, 170(4), 245-250 - The pharmacokinetics of succinylcholine (SCh) 1 or 2mg/kg was studied in 14 anesthetized patients. Arterial blood concentrations of SCh were measured using a high-performance liquid chromatographic assay. The arterial concentration vs. time data were analyzed by log-linear regression and fitted to an one-compartment model. The pharmacokinetic parameters were (SCh 1, n=8 and 2mg/kg, n=6): apparent volume of distribution (16.4±14.7 and 5.6±6.8ml/kg, mean±S.D. ), total body clearance (40.5±38.7 and 15.0±14.8liter/min), area under the plasma concentration-time curve (124.3±163.2 and 695.3±1008.9min•μg/ml), and elimination half-life (16.6±4.8 and 11.7±4.5sec). The rapid disappearance of SCh from the blood may be due to diffusion out of the blood vessel.
