The Tohoku Journal of Experimental Medicine
Online ISSN : 1349-3329
Print ISSN : 0040-8727
ISSN-L : 0040-8727
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Volume 170, Issue 4
Displaying 1-8 of 8 articles from this issue
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  • Neurite Promoting Activity of Collagens on Embryonic Neurons: Decreased Effect at the Postnatal Stage
    HIDEKI HIROSE, TETSUO KITAGUCHI, TAKESHI TABIRA
    1993Volume 170Issue 4 Pages 207-218
    Published: 1993
    Released on J-STAGE: August 31, 2006
    DOIhttps://doi.org/10.1620/tjem.170.207
    JOURNAL FREE ACCESS
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    HIROSE, H., KITAGUCHI, T, and TABIRA, T. Neurite Promoting Activity of Collagens on Embryonic Neurons: Decreased Effect at the Postnatal Stage. Tohoku J. Exp. Med., 1993, 170 (4), 207-218 - We studied the in vitro neurite outgrowth activity of fibronectin, laminin, heparan sulfate proteoglycan, type I collagen, type IV collagen, and type VIII collagen in cholinergic neuronal cell lines and primary cultured neurons. All these substances had high neurite promoting activity on primary cultured neurons from embryonic mouse brain. However, collagens had no such an effect on primary cultured neurons from postnatal brain. When neuronal cell lines were used, collagens and other extracellular matrix substances were equally and highly effective on cells originated from embryonic brain, but collagens were less effective on cells from postnatal brain. These findings suggest that postnatal neurons lose the neuritic responsiveness to collagens earlier than that of other ECM.
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  • Three Distinct Southern Blot Hybridization Patterns of HBV-DNA in the Sera of HBV Carriers
    MIKI YAMADA, MOTOYASU ISHII, MASAHITO MIURA, SHUICHI SATO, ATSUSHI KAN ...
    1993Volume 170Issue 4 Pages 219-228
    Published: 1993
    Released on J-STAGE: August 31, 2006
    DOIhttps://doi.org/10.1620/tjem.170.219
    JOURNAL FREE ACCESS
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    YAMADA, M., ISHII, M., MIURA, M., SATO, S., KANNO, A., OHORI, H. and TOYOTA, T. Three Distinct Southern Blot Hybridization Patterns of HBV-DNA in the Sera of HBV Carriers. Tohoku J. Exp. Med., 1993, 170 (4), 219-228 -The molecular species of hepatitis B virus (HBV)-DNA of 44 sera taken from 25 HBV carriers were examined by Southern blot hybridization with a biotin-labeled HBV-DNA probe and classified into three patterns. Type I consisted of two distinct bands of 4.0kb and 3.2kb. Type II consisted of the 4.0kb and 3.2kb bands and a smear between these two bands. Type III showed a broad band below 4.0kb. With endogenous HBV-DNA polymera