Abstract
Morphine hydrochloride was subcutaneously injected into normal rabbits, those doubly splanchnicotomized and those doubly suprarenalectomized in doses varying from 3 mgrms. to 30 mgrms. per kilo of body weight and the blood sugar concentration was measured from time to time.
Sectioning both the splanchnic nerves or removing both the glands reduces largely the intensity of the hyperglycaemia due to morphine; on moderate doses (15 mgrms. per kilo or so) the hyperglycaemia invariably occurred but only with such a degree of surplus as one second or third of the normal.
The resistance of doubly suprarenalectomized rabbits to morphine was definitely small when given a few days after the last decapsulation, compared with those long surviving.
