Hyperglycaemic Action of β=Dimethyltelluronium Dichloride

Abstract

β-dimethyltelluronium is capable of causing a hyperglycaemia. In rabbits 0.5-0.7 mgrm. per kilo of body weight was proved as effective in doing so when applied intravenously; 0.75mgrm. as the minimum lethal dose. Hypodermically about 1 mgrm. per kilo or more must be applied in order to evoke an increase in the blood sugar concentration. Double splanchnicotomy or double suprarenalectomy acts to reduce the magnitude of hyperglycaemia due to β-d. to some extent, and the latter somewhat powerfully.
6 to 7 mgrms. β-d. per kilo, intravenously applied, was proved also to have a hyperglycaemia action in dogs.