Abstract
0.0005-0.002 grm. nicotine per kilo was intravenously applied to normal rabbits. The results were not so uniform, but 0.001 grm. nicotine had a tendency to shorten the coagulation time of blood, while 0.0005 grm. and 0.002 grm. nicotine tended to lengthen it. 0.001 grm. nicotine was then tried on rabbits, doubly suprarenalectomized or medullisuprarenalectomized and indefinitely surviving. The coagulation time of blood was thereby either accelerated or retarded, sometimes remarkably, sometimes insignificantly.
That the loss of the epinephrine secreting mechanism has no significant influence upon the effect of nicotine upon the coagulation time of blood in rabbits when intravenously applied, is the general impression gained in the present researches. If nicotine is applied into the animal body, capable of influencing the coagulation time of blood only through the augmentation of the epinephrine discharge from the suprarenals, the coagulation time of animals deprived of either suprarenals or suprarenal medullae should remain unaltered in spite of receiving the nicotine, but it has not been realized in the present experiments.
