Abstract
Anaphylactic shock was induced in rabbits by means of horse serum. The animals were killed by a blow on the neck thirty minutes after injection of the antigen. The epinephrine store of the suprarenal glands, estimated by means of the colorimetric method of Suto and Kojima, was found to have diminished. When they were killed under severe anaphylactic conditions the depletion was larger, and when some recovery set in it was somewhat smaller.
The diminution became manifest in the suprarenal gland, which was also denervated beforehand.
Diminution of the epinephrine storage in anaphylaxis is not the result of accelerated liberation of epinephrine, but very probably of it destruction or some allied process.
