Studies on the Detoxicating Hormone of the Liver (Yakriton)

63rd Report. Effect of Yakriton* in a Comparatively Large Amount (2 R. A. U.) upon Blood Picture including Nuclear Shift

Abstract

If yakriton is subcutaneously injected in the amount of 2 R. A. U. (Rabbit-Ammonia-Units) per kilo of body weight into b-(low-) and f-(high-) classed rabbits, then the blood picture will be changed as described below:-
(1) Total white cell count. In the 3rd or 5th hour after the injection, leucocytes will increase to twice the number obtaining before the injection. The restoration of the number to normal will occur on the next day in b-classed animals, or on the third day in f-classed ones.
(2) Lymphatic leucocytes. They will show a decrease in number relatively, (to myeloic leucocytes) gradually after the injection, and reach the maximum (of decrease) in the 5th hour, but there will be no change of the absolute number of them. During the course of one week following the injection, they will show a very slight increase, and the maximal increase will fall on the 3rd day, in the case of f-classed animals.
(3) Myeloid leucocytes. They will show a remarkable increase in number, absolutely as well as relatively, after the injection. The restoration of the number to normal will not always occur on the next day. During the course of one week following the injection, they will show a general slight decrease; and in f-classed animals a remarkable decrease will occur on the 3rd day.
(4) Nuclear shift. The grade of nuclear shift will roughly correspond to the increase of the white cell count; and it will become in the b-classed three times, and in the f-classed four or five times, more severe than before the injection. The restoration of the shift to normal will not always occur on the next day. The shift is due to an increase of cells with rod-shaped nucleus and of those of Type II and, of course, to a decrease of those of Types III, IV and V.