Abstract
In the present investigations, we have proposed, using the last-ing preparations of the denervated heart of dogs deprived of the su-prarenal medullae, to determine on sustained administration for two minutes, the minimal effective dose of adrenaline for causing the dener-vated heart to beat faster, as well as the threshold value for elevating the blood pressure under normal, quiet conditions of animals.
The minimal effective dose of adrenaline for accelerating the heart is in the vicinity of 0.0002-0.0003 mgrm. per kilo per minute. Al-most the same dose was found as the threshold value for the blood pressure. And this minimal effective dose of adrenaline on sustained administration is five times or more as great as the quiet rate of the epinephrine discharge from the suprarenal bodies.
