In the present paper I wanted to test the antinephritic effect of yakriton for mercuric nephritis in rabbits. In 1933 T. Sato
4)5) of our Department treated rabbits of uranyl nephritis with yakriton suc-cessfully.
Mercuric nephritis, as was shown in a preceeding paper by Hasegawa and myself, was tried on individuals with different liver power, using
b- and
f-classed rabbits. While uranyl nephritis, according to T. Sa to was fatal to only the
b-classed, mercuric nephritis was fatal to both
b- and
f-classed animals. Mercuric nephritis is thus more severe than uranyl nephritis.
In the experiment proper 1.5 c. c. Of 1% HgCl
2 solution was used per kilo of body weight for the production of a fatal nephritis in
b-classed rabbits. And a daily subcutaneous injection of yakriton was tried. Among different numbers of units (1/2. 1/5, 1/10 and 1/20) used, only 1/10 R. A. U. per kilo of body weight was effectual for any eventual recovery from the poisoning for, as we have seen, this unit was able to rescue half the number of the poisoned rabbits.
Thus it will be seen that yakriton, the detoxicating hormone of the liver, is effectual for the detoxication of a kidney poison, and again that there is a close relation between the kidney and the liver.
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