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Volume 27 (1935)
- Issue 6 Pages 505-
- Issue 5 Pages 413-
- Issue 3-4 Pages 245-
- Issue 2 Pages 109-
- Issue 1 Pages 1-
Volume 27, Issue 1
Displaying 1-9 of 9 articles from this issue
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Masao Wada, Zyumpei Kanowoka1935 Volume 27 Issue 1 Pages 1-8
Published: August 31, 1935
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSThe inactivation of the suprarenal medulla either by bilateral demedullation or severance of the secretory nerves causes no consistent slowing of the basal rate of the denervated heart in situ in dogs well surviving the denervation.
This fact must be interpreted only as that the epinephrine is not liberated in a sufficient amount as to accelerate the denervated heart in situ in the quiet state of animals, but not further as to deny the liberation of epinephrine in any amount at all.View full abstractDownload PDF (363K) -
Masao Wada, Zyumpei Kanowoka1935 Volume 27 Issue 1 Pages 9-19
Published: August 31, 1935
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSIn the present investigations, we have proposed, using the last-ing preparations of the denervated heart of dogs deprived of the su-prarenal medullae, to determine on sustained administration for two minutes, the minimal effective dose of adrenaline for causing the dener-vated heart to beat faster, as well as the threshold value for elevating the blood pressure under normal, quiet conditions of animals.
The minimal effective dose of adrenaline for accelerating the heart is in the vicinity of 0.0002-0.0003 mgrm. per kilo per minute. Al-most the same dose was found as the threshold value for the blood pressure. And this minimal effective dose of adrenaline on sustained administration is five times or more as great as the quiet rate of the epinephrine discharge from the suprarenal bodies.View full abstractDownload PDF (840K) -
Hideo Kawano1935 Volume 27 Issue 1 Pages 20-37
Published: August 31, 1935
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSDownload PDF (993K) -
Studien über Flüssigkeitsaustausch. XXKenjiro Takeda1935 Volume 27 Issue 1 Pages 38-50
Published: August 31, 1935
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSWenn man an gesunden oder an mit Kantharidin bzw. Sublimat vergifteten überlebenden Krötennieren die Durchströmung mit Trypanblau-Ringerlösung von der Niereuarterie oder von der Nieren-pfortader aus ausgeführt hat, so ergibt sich folgenden:
1. Die Glomeruli der gesunden Nieren lassen Trypanblau ziem-lich leicht durch, während die Nierenepithelien sich dagegen gegenüber dem Durchgang des Trypanblaues fast völlig hemmend verhal-ten.
2. Die Glomeruli der Kantharidinnieren sind für Trypanblau meter durchlässig als derselben der gesunden Nieren. Allein das hem-mende Verhalten der Nierenepithelien gegenüber dem Durchtritt dieses Farbstoffes ist nahezu analog demselben der gesunden Nierenepithe-lien.
3. Die Glomeruli der Sublimatnieren lassen die Passage des Trypanblaues zu, und das durch sie filtrierte Trypanblau wird im Tubu-luslumen rückresorbiert. Auf Grund des Befundes, dass die glomeruläre Filtration vielmehr lebhaft vor rich geht, kann man die Oligurie bzw. Anurie bei nekrotischen Nieren, im Ansehluss an Yamaguchi's Ansicht, als durch eine regellose Rückresorption in den Tu-buli, welche durch I-Ierabsetzung bzw. Aufhebung der Nierenepi-thelfunktion herbeigeführt worden ist, bedingt auffassen.
4. Zugeführtes Trypanblau wird aus den Nierenepithelien nicht aktiv ausgeschieden. Die der Nekrose verfallenden Nierenepithelien werden mit zugeführtem Farbstoff von hinten aus dem die Tubuli umspinnenden Kapillarsystem her gefärbt.
5. Aus obigen Ergebnissen geht hervor, dass bei Kantharidin-nieren vorwiegend die filtrationsregulierende Kraft der Glomeruli, bei Sublimatnieren vornehmlich die rückresorptionsregulierende Fähigkeit der Nierenepithelien Einbusse erleidet.View full abstractDownload PDF (1531K) -
Studien über Flüssigkeitsaustausch. XXIKenjiro Takeda1935 Volume 27 Issue 1 Pages 51-64
Published: August 31, 1935
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSDownload PDF (760K) -
Masao Wada, Mitizane Seo, Kimio Abe1935 Volume 27 Issue 1 Pages 65-86
Published: August 31, 1935
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSDogs, in which the operation area was previously de-afferented, were experimented on. The procedure for collecting the suprarenal vein blood through the lumbar approach was performed, namely with-out their being fastened or without their giving any evidence of pain. The dogs were compelled to run on a paved road or in a revolving wheel.
(1) When the animals presented no signs of fatigue or were tired slightly after a run of 360 to 6840 meters, the rate of the epinephrine secretion remained almost unaltered, while in the animals which were much fatigued or exhausted, by running 760 to 2565 meters, the rate was increased from the quiet value of 0.000015-0.000025 mgrm. from one suprarenal capsule per kilo and per minute to 0.00003-0.0001 mgrm.: This peak being noted a few minutes or about a half hour after running. The magnitude of acceleration was thus very small and its duration was short, ad maximum about one hour after run-ning. Whether the epinephrine discharge will be accelerated, though only a little, depends directly upon the condition of the animal, whe-ther exhausted or not, and not directly upon the magnitude of the work.
(2) In cases where the animals presented no signs of exhaustion, the blood from the femoral artery, taken soon after cessation of the muscular exertion, exhibited only a slight rise of the glycaemic level or no change. In cases where the animals were exhausted from the muscular effort, the glycaemic percentage showed a tendency to de-crease, though slightly, sooner or later.View full abstractDownload PDF (1523K) -
Shizuka Sato1935 Volume 27 Issue 1 Pages 87-94
Published: August 31, 1935
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSAus den obigen Versuchen geht sehr deutlich hervor, dass die Abkühlung der Bauchwand, besonders in der Epigastrialgegend die sensiblen Nervenenden an der betreffenden Stelle in Erregung versetzt, wodurch dann die Zentren des autonomen Nervensystems ebenfalls in Erregung geraten. Von diesen wird das parasympathische Zentrum stärker, aber etwas später als das sympathische erregt, sodass im Magen nach einer vorübergebenden unbedeutendenTonusherabsetzung und Peristaltikabschwächungeine deutliche Tonussteigerung und Peristaltikverstärkung erfolgen, die hochstwahrscheinlich die Ursache des Magenschmerzes bei einer Abkühlung des Bauches sind. Eine starke Abkühlung der Epigastrial-gegend verursacht indessen eine Temperatursenkung des Magens, die im Gegensatz zu der schwachen Abkühlung eine deutliche Tonussen-kung und Peristaltikabschwächung zur Folge hat.View full abstractDownload PDF (1831K) -
64th Report. Mercuric Nephritis in Individuals with Different Liver Power of DetoxicationJunkichi Asano, Mitsuru Hasegawa1935 Volume 27 Issue 1 Pages 95-98
Published: August 31, 1935
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSMercuric nephritis was produced in rabbits with different liver power of ammonia-detoxication, namely in three b-classed and three f-classed rabbits. They all succumbed to the poisoning, but the f-classed animals (of high-classed detoxicating liver power) survived the intoxication on an average twice as long as the b-classed ones (of low-classed detoxicating liver power). Besides, the difference was also seen in the point of the blood urea content (Cf. Figure).View full abstractDownload PDF (160K) -
65th Report. Effect of Yakriton upon Mercuric NephritisJunkichi Asano1935 Volume 27 Issue 1 Pages 99-108
Published: August 31, 1935
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSIn the present paper I wanted to test the antinephritic effect of yakriton for mercuric nephritis in rabbits. In 1933 T. Sato4)5) of our Department treated rabbits of uranyl nephritis with yakriton suc-cessfully.
Mercuric nephritis, as was shown in a preceeding paper by Hasegawa and myself, was tried on individuals with different liver power, using b- and f-classed rabbits. While uranyl nephritis, according to T. Sa to was fatal to only the b-classed, mercuric nephritis was fatal to both b- and f-classed animals. Mercuric nephritis is thus more severe than uranyl nephritis.
In the experiment proper 1.5 c. c. Of 1% HgCl2 solution was used per kilo of body weight for the production of a fatal nephritis in b-classed rabbits. And a daily subcutaneous injection of yakriton was tried. Among different numbers of units (1/2. 1/5, 1/10 and 1/20) used, only 1/10 R. A. U. per kilo of body weight was effectual for any eventual recovery from the poisoning for, as we have seen, this unit was able to rescue half the number of the poisoned rabbits.
Thus it will be seen that yakriton, the detoxicating hormone of the liver, is effectual for the detoxication of a kidney poison, and again that there is a close relation between the kidney and the liver.View full abstractDownload PDF (474K)
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