Abstract
If yakriton is subcutaneously injected in the amount of 10 R. A. U. per kilogram of body weight into b- and f-classed rabbits, then the blood picture will be changed as follows:-
1. Total white cell count. A remarkable leucocytosis in f-classed animals, and a slight leucocytosis in b-classed animals will be seen, reaching the maximum in the 4th or the 5th hour after the injection. During the whole course of one week a slight leucocytosis, in both cases.
2. Lymphatic cells. A relative lymphopenia in the b-classed, and a lymphopenia, absolute as well as relative, in the f-classed, will be seen, the maximum being reached in about the 4th or the 5th hour after the injection. During the whole course following the injection, they will show a slight increase, and the maximal increase will fall on the 5th day in the f-classed, and at the end of the 7th day in the b-classed.
3. Myeloid cells. A remarkable myelocytosis, absolute as well as relative, in both cases, the maximum occurring in the 4th or the 5th hour after the injection. During the whole course of one week, they will show a slight decrease. A considerable decrease will occur on the 4th day in the f-classed, and on the 7th day in the b-classed.
4. Nuclear shift. A remarkable shift of a regenerative nature will occur gradually after the injection, and it will become in the b-classed three or four, and in the f-classed, four or five times the normal. During the whole course of one week, a slight shift will continue in the f-classed up to the end of the week, and in the b-classed up to the 2nd or the 3rd day after the injection. This shift is due to an increase of cells with rod-shaped nucleus and of those of Types II and, of course, to a decrease of those Types III, IV and V.
