1935 年 27 巻 2 号 p. 218-244
The lobulus posterior medianus of the cerebellum was punctured in the dogs, non-anaesthetized, non-fastened and the epinephrine se-cretion rate was determined by collecting the suprarenal vein blood through the lumbar approach and the rabbit intestine segment method as well as the paradoxical cat pupil method.
(1) On puncturing, the epinephrine output rate increased, the acme being reached about five to fifteen minutes later, and the in-creased secretion lasted for one to two hours. The acceleration was generally small, the excess being 0.00015-0.00035 mgrm. epinephrine per kilo per minute from both glands, about one third of that achiev-able by the piqure diabetique of Cl. Bernard.
The total amount secreted from both glands during two hours after the puncture of the posterior portion of the lobulus posterior medianus was on an average 0.012 mgrm. per kilo of body weight, also one third of the piqure diabetique.
(2) The blood sugar concentration was only slightly influenced by the puncture of the lobulus postorior medianus, contrary to the piqûre diabétique of Cl. Bernard, and in fact contrary to the previ-ous experimentalists. In most cases it increased, but only insigni-ficantly, having a maximal increase of 0.02%. That previous experi-mentalists obtained an excessive hyperglycaemia by destroying the cerebellum might be due to some complicated experimental condi-tions, which vitiate the outcome. The present writers are therefore of the view that the vermis has no special significance in the carbo-hydrate metabolism, contrary to some previous authors.
(3) The arterial blood pressure ascended invariably on punctur-ing, while some previous experimentalists failed to see any ascent. Its amount seemingly depends upon the region which was punctured; when the portion posterior to the fissura second was extensively at-tacked it was large and continued somewhat long. Destruction of the vermis before the fissrue causes only a transitory and a somewhat smaller rise. The heart rate increased in most cases, but usually in a small degree; never was diminution noted, contrary to the piqure diabétique. Tne increase continued usually for some minutes. The respiration rate increased too.
(4) In conclusion it may be added here that the puncture of the portion of the lobulus posterior medianus posterior to the fissura se-cunda brought about nystagmus without exception.
