抄録
Epinephrine output rate was measured in dogs, the operation field of which was previously de-afferented. The suprarenal vein blood was collected by the lumbar approach, without their being fastened or anaesthetized. Epinephrine was estimated against the adrenaline hydrochloride solution of Sankyo Co., by means of the rabbit intestine segment and of the cat paradoxical pupil.
Lobelin was proved as producing an over-secretion of the epine-phrine liberation rate and an increase of the blood sugar concentration; it was applied here hypodermically in doses of from 10 mgrms. to 1.25 mgrms. per kilo of body weight, the augmentations were always noted, and 1.25 mgrm. was found as the threshold dose for doing so. The augmentation was however of small magnitude, as by 0.00005 mgrm. epinephrine per kilo per minute from one gland, and the degree of hyperglycaemia was also small. The therapeutic dose can have no in-fluence upon the epinephrine output rate and the blood sugar con-centration, if the figures obtained in the experiment on dogs be ap-plicable to man.
