The Tohoku Journal of Experimental Medicine
Online ISSN : 1349-3329
Print ISSN : 0040-8727
ISSN-L : 0040-8727
Studies on the Detoxicating Hormone of the Liver (Yakriton)
70th Report. Preliminary Report of the Effect of Liver Insufficiency on the Course and the Blood Picture of Rabbit Tuberculosis
Ryoji Shibata
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1936 Volume 28 Issue 1 Pages 82-89

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Abstract
The difference of the blood pictures between controls and rabbits with ammonia injection which were both inoculated with 3 mgrms. of tubercle bacilli (human type) intraocularly, was as follows:-
1. Total white cell count. Control animals showed a remarkable leucocytosis or a leucopenia. Rabbits with a leucocytosis survived longer than those with a leucopenia. Contrarily the rabbits with ammonia-injection showed a leucopenia and died in a few weeks.
2. Lymphatic and myeloid cells. In the case of controls a lymphopenia and a myelocytosis were seen; these changes were more remarkable at the end of this experiment. On the contrary, the rabbits with ammonia-injection showed a shift to the right and the shift was obviously of a degenerative nature.
3. Monocytes, eosinophiles and basophiles. Control animals showed a remarkable monocytosis, but in the case of animals with ammonia injection only a slight monocytosis occurred. Eosinophiles decreased in both cases and disappeared entirely before the death. Basophiles showed a slight increase in both cases.
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© Tohoku University Medical Press
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