Abstract
Rhodein, a glucosid isolated from rhodea japonica Roth and clinically much used in this country as a cardiotonica and diuretica, was intravenously applied to the dogs with the lumbar route prepara-tion for collecting suprarenal venous blood without fastening, nar-cotizing or laparotomizing. Epinephrine was determined by means of the rabbit intestine segment.
(a) When sufficient doses, such as 0.8-0.9 mgrm. rhodein per kilo body weight were intravenously applied, the epinephrine output rate was increased largely. While in some cases the increase occurred concurrently with development of usual poisoning symptoms, there was in one case an enormous increase, which developed in a later stage and actually when the animal became fatigued and depressant.
(b) The blood sugar content was decreased in the rhodein intoxication. (c) As, rhodein has been tested for the first time in dogs, some words may be added: 0.8 mgrm. rhodein per kilo, may be the intra, venous minimum lethal dose for dogs.
Rhodein evokes in dogs some similar symptoms as in cats. Nau-sea, vomiting, laboured respiration, defaecation, urination. Tem-porary slowing in the heart rate, and an elevation in the arterial blood pressure, which continues very long when sufficient amount is given.
