The Tohoku Journal of Experimental Medicine
Online ISSN : 1349-3329
Print ISSN : 0040-8727
ISSN-L : 0040-8727
Influence of Diphtheria Toxine on the Epinephrine Content of the Suprarenals in Rabbits
Takeo Mutow
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1937 Volume 31 Issue 3-4 Pages 319-330

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Abstract
Rabbits were poisoned with diphtheria toxine; a dose capable of killing them just within 24 hours, its fivefold and fifteenfold quantities were given. After killing animals at various times after intravenous injection, as 1 hour, 6 hours, 12 hours and 24 hours, usually by a blow on the neck, the epinephrine content was estimated by means of the Suto-Iiojima method. In an early stage of intoxication, indicated by a small rise of the body temperature, the epinephrine content began to diminish but only insignificantly. With the appearance of diarrhoea and body temperature fall, the load was then estimated as obviously diminished. Cutting the splanchnic nerves was proved as checking the diminishing to some extent.
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