Abstract
I investigated the therapeutic effect of yakriton on experimental chromate nephritis from urine protein content, and examined, besides, the functional kidney test by means of phenolsulphonphthalein. I ob-tained the following results:-
1. Experiment 1. In this experiment 0.5% aqueous solution of potassium chromate was injected in the amount of 0.5 c. c. per kilo of body weight. Control animals were put to urine examination and kidney. function test on the 4th day of the poison injection. And the yakriton animals were injected with yakriton in the amount of 1/4 R. A. U. per kilo of body weight (once a day) 4 times after the poison injection and put to the same tests, as has been shown in Fig. 1. Urine protein content of the control animals was somewhat larger than that of the yakriton animals (Cf. Tables 1 A and B). The total amount of the dye excreted through the kidneys in the 1st 4 hour portion was smaller by 10.8% in the control animals, and larger by 2.7% in the yakriton animals, than the normal (Cf. Table 4).
2. Experiment 2. This experiment differed from Exp. 1 only in the amount of poison used. In this experiment it was used in 1 c. c. per kilo of body weight instead of 0.5 c. c.. Urine protein content of the control animals was larger than that of the yakriton animals (Cf. Tables 2 A and B). The total amount of the dye excreted in the urine in the 1st 4 hour portion was smaller by 42.5% in the control animals, and by 2.6% in the yakriton animals, than in the normal (Cf. Table 4).
