Abstract
In order to test the fallacy that the paradoxical pupil reaction occurs only in a small degree while the denervated heart continues to increase largely in the animals with demedullated suprarenals, when coldness is applied to their body, the reactions were estimated simultaneously in one and the same dog.
Both organs were wholly denervated, and in fact the pupil was denervated about ten days before the cooling experiment. For cooling cold water was introduced into the stomach through the stomach fistula. The heat debt was chosen as about three thousand calories per kg of body weight.
At first it must be emphasized that both reactions don't occur11) quite simultaneously, viz. the latency, the time when the reaction reaches its maximum, and the whole duration are decidedly shorter for the pupil reaction in comparison to the denervated heart acceleration. This finding is applicable to the dogs, with the normal suprarenals and the demedullated as well.
When the suprarenals were demedullated, the cold application was capable to accelerate the denervated heart just as before, but difficult to dilate the denervated pupil, that is, the paradoxical pupil reaction occurred only in incomparatively small mass.
The time relation between both reactions and the body temperature fall and the shivering seizures are given in the text, and the relation between both reactions and the epinephrine secretion is discussed also in the text though not so conclusively.
The author wishes to thank Dr. M. Wada, Assistant Professor, for hav-ing helped me by denervating the heart.
