Abstract
Sampling the adrenal vein blood in dogs without anesthetizing, fastening or evoking pain, the adrenaline secretion rate before and after alloxan was estimated. Blood sugar content was measured simultaneously.
After alloxan the blood sugar content increased definitely. This initial hyperglycemia was followed by the hypoglycemia. The adrenaline secretion rate remained unaltered until an intense hypoglycemia took place. Therefore we can not accept the view of some authors that the initial alloxan hyperglycemia is due to the augmented adrenaline secretion from the adrenals.
At the hypoglycemic phase a definite acceleration of the adrenaline secretion was observed. Its maximum values were measured as 0.14-0.17μg. per kg. per min. from the adrenal gland of one side.
The expense of this investigation has been defrayed in part by a grant from the Ministry of Education. T. S.
