1. ChE activity in the cerebrospinal fluid of 140 patients of various nervous diseases was measured manometrically, using Warburg's apparatus.
2. The value of ChE was expressed with CO
2 cubic mm. peroduced per 1 cc. cerebrospinal fluid per 30 minutes.
3. ChE in the cerebrospinal fluid is much weaker than in the serum or the brain tissue, and its value varies independently of change in the serum ChE value.
4. Increased ChE activity of the cerebrospinal fluid was found in tuberculous meningitis and tumor of brain and spinal cord, while in poliomyelitis, progressive paralysis and epilepsy the value was found to be lowered.
5. No abnormal value of ChE in cerebrospinal fluid was confirmed in the following diseases: flaccid and spastic hemiplegia following cerebral hemorrhage, paralysis agitans, periodic paralysis, chorea minor, spastic spinal paralysis, myasthenia gravis, myotonia congenita, progressive muscular dystrophy, etc.
6. The physiological role of ChE in cerebrospinal fluid was discussed.
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