On the Minimal Effective Dose of Noradrenaline for Causing the Blood Pressure Elevation in Non-Anesthetized Dogs

Abstract

Injecting intravenously DL-noradrenaline at the uniform rate during 5 minutes, the minimal effective dose for causing the blood pressure elevation was determined in non-anesthetized normal dogs. It was estimated to be 0.3-0.4μg. per kg. per minute.
In addition, the pressor effects of L-noradrenaline, DL-noradrenaline and L-adrenaline were compared in non-anesthetized normal dogs. L-noradrenaline was double as much effective as DL-noradrenaline and 1.6-2.0 times as much active as L-adrenaline.
As the pressor effect of L-noradrenaline is twice as much as that of DL-noradrenaline, the minimal effective does of L-noradrenaline for causing the elevation of the blood pressure in non-anesthetized normal dogs will be 0.15-0.2μg. per kg. per minute.
My thanks are due to Prof. T. Suzuki for his helpful advice.