The Tohoku Journal of Experimental Medicine
Online ISSN : 1349-3329
Print ISSN : 0040-8727
ISSN-L : 0040-8727
Contribution to the Ocular Manifestation of Riboflavin Deficiency
Kimiho IrinodaSeizo Sato
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1954 Volume 61 Issue 1 Pages 93-104

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Abstract
By clinical observation on so-called “Shibi-Gattchaki” patients and the experimental study on young riboflavin-deficient rabbits we have ob-tained the following results;
1. The deficiency of riboflavin mostly caused degenerative changes (vacuolar degenerations), regenerative process (compensatory vascularization) and reactive chronic inflammation in the avascular or hypovascular
organ such as the cornea, inner layer of the retina.
2. Ocular manifestation of ariboflavinosis including its latent state occurred considerably frequently in human beings as well as in animals, as compared with other signs.
3. Ocular symptom, like other various clinical signs, are patho-gnomonically reliable.
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© Tohoku University Medical Press
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