Abstract
1. Tryptase, ereptase, catheptic proteinase and peptonase activities are lowered in the liver under anaphylactic shock state, when antigen is reinjected through the portal vein directly to the liver. In such cases tryptase and ereptase activities in the kidney are lowered too. But when antigen is reinjected through the systemic vein, such retardation of the protease activities is not so manifest.
2. Delivery of acetylcholine through the systemic vein produces activation of the liver protease system but through the portal vein it produces no change.
3. Anoxic state of the liver produces neither retardation nor activa-tion of the protease system in the liver or in the kidney.
4. Gastric mucosa proteolysis undergoes no change under each of above conditions.
5. Liver or kidney is not likely to play the main role in protein catabolic response to stimuli such as anaphylactic shock state.
This work was carried out by a grant for development of scientific re-searches, given from the Ministry of Education. M. Hayakawa
