The Tohoku Journal of Experimental Medicine
Online ISSN : 1349-3329
Print ISSN : 0040-8727
ISSN-L : 0040-8727
Volume 62, Issue 1
Displaying 1-10 of 10 articles from this issue
  • V. Protease Activity of Tissues under Anaphylactic Shock State (Directed by Asst. Prof. M. Hayakawa)
    Fumio Ito
    1955 Volume 62 Issue 1 Pages 1-9
    Published: June 25, 1955
    Released on J-STAGE: November 28, 2008
    JOURNAL FREE ACCESS
    1. Tryptase, ereptase, catheptic proteinase and peptonase activities are lowered in the liver under anaphylactic shock state, when antigen is reinjected through the portal vein directly to the liver. In such cases tryptase and ereptase activities in the kidney are lowered too. But when antigen is reinjected through the systemic vein, such retardation of the protease activities is not so manifest.
    2. Delivery of acetylcholine through the systemic vein produces activation of the liver protease system but through the portal vein it produces no change.
    3. Anoxic state of the liver produces neither retardation nor activa-tion of the protease system in the liver or in the kidney.
    4. Gastric mucosa proteolysis undergoes no change under each of above conditions.
    5. Liver or kidney is not likely to play the main role in protein catabolic response to stimuli such as anaphylactic shock state.
    This work was carried out by a grant for development of scientific re-searches, given from the Ministry of Education. M. Hayakawa
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  • Fourth Paper On Placental Non-Hexuronic Acid-Containing Mucopolysaccharide
    Yosizi Mugikura
    1955 Volume 62 Issue 1 Pages 11-17
    Published: June 25, 1955
    Released on J-STAGE: November 28, 2008
    JOURNAL FREE ACCESS
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  • CLXXVIII. On Molecular Aggregation in Solution of a Group-active Mucopolysaccharide from Pig Stomach Mucus
    Yuh-iti Suzuki
    1955 Volume 62 Issue 1 Pages 19-26
    Published: June 25, 1955
    Released on J-STAGE: November 28, 2008
    JOURNAL FREE ACCESS
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  • Masakazu Saheki
    1955 Volume 62 Issue 1 Pages 27-39
    Published: June 25, 1955
    Released on J-STAGE: November 28, 2008
    JOURNAL FREE ACCESS
    With a view to ascertaining whether bacteria can pass through the normal kidney, suspensions of 5 species of nonpathogenic bacteria were abundantly injected into the ear veins of rabbits, samples of the bladder urine were taken by direct puncture of the previously exposed bladder, and the urine samples were incubated and tested for bacteria, with the results to be summarized as follows:
    1. With B. subtilis and an enterococcus, the bladder urine constantly remained sterile, in relatively many cases, throughout the period of examina-tion from 0.5 to 7 hours after injection (8 samples). Similar results were obtained in a few cases with other species of bacteria. These results are in support of the view denying the passage of bacteria through the normal kidney.
    2. In some cases, the bladder urine was sterile at first but became positive 3 or 4 hours after injection. In the positive urine samples con-current appearance of erythrocytes was demonstrated. From the common knowledge as to the excretion by the normal kidney of pigment or some other foreign body, those bacteria that appeared in the bladder urine first after 3 or 4 hours cannot be regarded to have been excreted by the kidney, but may possibly be what had transferred from the blood stream into the bladder urine on account of bleeding due to puncture of the bladder.
    3. With avirulent B. coli which is the most actively multiplying and best growing species of the bacteria tested, it was often the case that the appearance of bacteria in the urine was in advance of that of erythrocytes. In experiments of bilateral ligature of the ureters (with avirulent B. coli) also similar cases were observed when bacteria in the blood stream trans-ferred directly to the bladder urine.
    4. These results may be taken to be in favor of the view denying the passage of bacteria through the normal kidney.
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  • Kyoichi Monma
    1955 Volume 62 Issue 1 Pages 41-51
    Published: June 25, 1955
    Released on J-STAGE: November 28, 2008
    JOURNAL FREE ACCESS
    In order to settle the question whether bacteria can pass through the normal kidney, suspensions of 5 strains of pathogenic bacteria were injected into the ear veins of rabbits, samples of the bladder urine were obtained by direct puncture of the previously exposed bladder, and the urine samples were cultivated to test for bacteria, with the results to be summarized as follows:
    1. Those results that the bladder urine remained constantly sterile throughout the period of examination after injection (from 0.5 to 7 hours after injection) were obtained from 8 cases with Mycobacterium tuberculosis, from 5 cases with B. typhosus, from 4 cases with Staphylococcus aureus of Tera-shima strain, and from 3 cases with that of Heatley strain, namely, from 20 cases out of 34 cases in total, which results are against the view that bacteria can pass through the normal kidney.
    2. The bladder urine had been sterile for a short period of time after injection. In some cases they became positive for bacteria later on account of contamination of the urine with blood, which was caused by bleeding due to puncture of the bladder.
    3. Most of the cases with B. pyocyaneus and only a few of the cases with Staphylococcus aureus of Terashima strain yielded the results that bac-teria were detected in advance of the appearance of erythrocytes. It has been demonstrated by a series of experiments of ligating the bilateral ureters that such a phenomenon may be seen with actively multiplying and well growing bacteria.
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  • I. On the Origin of Gastric Ulcer-Carcinoma
    Susumu Majima
    1955 Volume 62 Issue 1 Pages 53-61
    Published: June 25, 1955
    Released on J-STAGE: November 28, 2008
    JOURNAL FREE ACCESS
    1. Examination was made of 18 cases with ulcer-carcinoma in early stages by the serial section method.
    2. Ulcer-carcinoma seems to originate from regenerative epithelium of atypical proliferation.
    3. In 11 of the 18 cases with early ulcer-carcinoma, multicentric development of cancer foci has been demonstrated at the ulcer margin or in the mucous membrane apart from the ulcer margin. In the re-maining 6 cases, except 1 case in which a small cancer focus was found in a very small portion of the ulcer margin, cancer foci extended to surround the ulcer margin completely or almost completely, being thus suggestive of the fusion of multicentrically developed cancer foci.
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  • II. On the Growth of Ulcer-Carcinoma
    Susumu Majima
    1955 Volume 62 Issue 1 Pages 63-73
    Published: June 25, 1955
    Released on J-STAGE: November 28, 2008
    JOURNAL FREE ACCESS
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  • S. Majima, J. Katami, N. Kurakake, N. Hoshi
    1955 Volume 62 Issue 1 Pages 75-80
    Published: June 25, 1955
    Released on J-STAGE: November 28, 2008
    JOURNAL FREE ACCESS
    An investigation has been made on the late results of gastrectomy with 60 cases of ulcer-carcinoma where operation was performed more than one year ago, with the results to be summarized as follows : In cases of ulcer-carcinoma of grades 1 to 3 of deep infiltration, late results of operation are favorable, whereas the results are very unfavorable in cases of ulcer-car-cinoma of grade 4.
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  • XX. Interconversion in vitro of Blood Groups A and B
    Hajime Masamune, Ziroh Akama
    1955 Volume 62 Issue 1 Pages 81-91
    Published: June 25, 1955
    Released on J-STAGE: November 28, 2008
    JOURNAL FREE ACCESS
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  • I. Experimentally Established Tuberculous Bronchial Ulcer in Dog
    Katsumi Kozu
    1955 Volume 62 Issue 1 Pages 93-104
    Published: June 25, 1955
    Released on J-STAGE: November 28, 2008
    JOURNAL FREE ACCESS
    From the view point of implanatation theory on the tuberculous tracheobronchitis, tuberculous bronchial ulcer was experimentally estab-lished by attaching tubercle bacilli of human type on the main bronchus of dogs by various methods.
    1. In the normal bronchial mucosa, ulceration was not caused by repeated painting of tubercle bacilli on the site twice a week for a period of 5 weeks.
    2. Ulceration was produced when bacilli painting was done on the inflammatory or the scratching site previously made on the mucosa.
    3. Ulceration was caused always by repeated submucous injections of bacilli but not by a single injection.
    4. From these results, locus minolis resistentiae and repeated in-vasions of bacilli are considered to be favourable factors for the develop-ment of tracheobronchial tuberculosis.
    5. In case submucous injection with bacilli was tried one to four weeks after an abdominal injection, no marked difference was observed as compared with the case of similar injection without any preliminary procedure.
    6. In the group of long period observation after pulmonary injec-tion, mucous epithelial cells of the orifice of the lobe bronchus were found necrotic or partly desquamating due to the attaching of secretion., that brought tubercle bacilli from the pulmonary lesions especially from cavities. Peripheral bronchiolus-wall without cartilage was easily influenced by the surrounding pulmonary lesions, whereas the bronchus with cartilage was hardly affected.
    7. When bacilli were painted after applying arsenious-acid paste, there was a marked bronchial stenosis which was mostly cicatricial, while in the case of repeated injections of bacilli, the stenosis was also marked owing to the thickness of mucous membrane and to the swelling of hilar lymph nodes.
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