The Tohoku Journal of Experimental Medicine
Online ISSN : 1349-3329
Print ISSN : 0040-8727
ISSN-L : 0040-8727
Chemical Studies of Carcinoma
XIV. A Toxic Substance Found in Gastric Carcinoma and its Effect on the Excised Frog Heart
Kunihiro Maki
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1956 Volume 63 Issue 2-3 Pages 121-131


1. The extract of gastric carcinoma in distilled water, Ringer's solu-tion for frogs or 2.5 per cent saline presented an inhibiting effect on the excised frog heart more than four times as strong as that of the extract of normal human gastric mucosa when studied by the kymographic method.
2. When the extract was dialyzed across the cellophane membrane for 48 hours the heart-inhibiting substance was demonstrated in the dialyzate, not in the dialyzed extract.
3. Various chemical and physical treatments were submitted to this substance to study its nature, and it was found that the inhibiting sub-stance was absorbed by cation exchange resin, and soluble in alcohol and chloroform.
In conclusion, I wish to express my sincere gratitude to Assistant Professor K. Ishizuka of the Pharmacological Institute and to Dr. H. Kawasaki of the Medicochemical Institute of Tohoku University.

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