The Tohoku Journal of Experimental Medicine
Online ISSN : 1349-3329
Print ISSN : 0040-8727
ISSN-L : 0040-8727
Volume 63 , Issue 2-3
Showing 1-21 articles out of 21 articles from the selected issue
  • Katsutaro Kobayashi, Osamu Ogata, Nobuo Kimura
    1956 Volume 63 Issue 2-3 Pages 109-120
    Published: February 25, 1956
    Released: November 28, 2008
    JOURNALS FREE ACCESS
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  • Kunihiro Maki
    1956 Volume 63 Issue 2-3 Pages 121-131
    Published: February 25, 1956
    Released: November 28, 2008
    JOURNALS FREE ACCESS
    1. The extract of gastric carcinoma in distilled water, Ringer's solu-tion for frogs or 2.5 per cent saline presented an inhibiting effect on the excised frog heart more than four times as strong as that of the extract of normal human gastric mucosa when studied by the kymographic method.
    2. When the extract was dialyzed across the cellophane membrane for 48 hours the heart-inhibiting substance was demonstrated in the dialyzate, not in the dialyzed extract.
    3. Various chemical and physical treatments were submitted to this substance to study its nature, and it was found that the inhibiting sub-stance was absorbed by cation exchange resin, and soluble in alcohol and chloroform.
    In conclusion, I wish to express my sincere gratitude to Assistant Professor K. Ishizuka of the Pharmacological Institute and to Dr. H. Kawasaki of the Medicochemical Institute of Tohoku University.
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  • Ototaka Higashi, Hisashi Kagaya, Tadashi Hayashi, Tsunehisa Sutoh
    1956 Volume 63 Issue 2-3 Pages 133-136
    Published: February 25, 1956
    Released: November 28, 2008
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  • Toshio Kurosawa, Shin'itiro Katayama
    1956 Volume 63 Issue 2-3 Pages 137-144
    Published: February 25, 1956
    Released: November 28, 2008
    JOURNALS FREE ACCESS
    By the method of electro-stimulation, retinal induction was measured at various parts of the human retina.
    1. The magnitude of retinal induction was found greatest at about 10° from the fovea. This fact might be correlated with the psychological fact that color contrast can most easily be perceived in the para-foveal region of the retina.
    2. Red and green lights were found more effective in producing retinal induction than yellow and blue lights.
    3. In measurements of retinal induction two photic stimuli are used, i.e., a colored light preceding a white test light. The intensity of retinal induction was shown to be independent of the intensity and the duration of the white test light, but determined by those of the inducing colored light. This law holds good for both foveal and peripheral vision.
    The authors are indebted to Prof. K. Motokawa for his invaluable advice and encouragement.
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  • Itaru Ohara
    1956 Volume 63 Issue 2-3 Pages 145-151
    Published: February 25, 1956
    Released: November 28, 2008
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    The blood vessels in 50 fresh canine hearts which were removed from the body were studied. Various injection methods were used to outline its distribution. Models using methacrylate were found to be the best to obtain the relationship of the vessels. Importance of the anatomy in case of studying the effect of ligation of the vessels were emphasized.
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  • Itaru Ohara
    1956 Volume 63 Issue 2-3 Pages 153-169
    Published: February 25, 1956
    Released: November 28, 2008
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    According to the anatomical study of the canine heart, abundant collaterals were found existing in the heart. In order to open them up and increase the extracardiac blood flow, coronary sinus was constricted to 3mm. after 1) pericarditis was caused by talc powder, 2) great omentum, and 3) left major pectoralis muscle was sutured to the myo-cardium. The dogs did not survive the ligation of the origin of the anterior descending branch of the left coronary artery. Either single constriction or ligation of the coronary sinus did not protect the heart from ligating the anterior descending branch. Such procedures to prevent the outflow of of the coronary venous blood do not seem to contribute to increase the intercoronary anastomosis.
    Implantation of the left internal mammary artery into the myocardium will make good anastomosis with the heart muscle as far as it is patent. However, the incidence of thrombosis is considerably high.
    As dissection of coronary sinus is met with imminent bleeding, an-astomosis is quite difficult to establish complete arterialisation of coronary sinus. The procedure cannot be recommended as a safe operation.
    The work was supported by grants for the research group of Coronary Circulation and Cardiac surgery from the Scientic Research Fund by the Edu-cation Ministry, 1953, and 1954, respectively.
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  • Hideo Odashima
    1956 Volume 63 Issue 2-3 Pages 171-184
    Published: February 25, 1956
    Released: November 28, 2008
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    1. The glomerular filtration rate, renal plasma flow, renal blood flow, filtration fraction and calculated renal vascular resistance were estimated in 5 normotensive, 20 benign and malignant hypertensive and 5 renal hypertensive subjects.
    2. The acute effect on renal hemodynamics of hexamethonium, veratrum alkaloids or apresoline, parenterally administered, were investigat-ed in 28 hypertensive patients including 23 benign and malignant hyper-tension and 5 renal hypertension.
    In benign hypertension, there were in general an increase in renal plasma flow, renal blood flow, and a reduction in filtration fraction or renal vascular resistance following the administration of each hypotensive agent, but glomerular filtration rate shows a slight increase after hexa-methonium and no change or slight decrease after veratrum or apresoline.
    In malignant hypertension and in renal hypertension, though in the latter to a less degree, the glomerular filtration rate, renal plasma flow, renal blood flow and filtration fraction are reduced, common to all three drugs, but renal vascular resistance shows a depression after veratrum and an increase after hexamethonium or apresoline. Differences between the responses to each agent are not significant.
    3. It is discussed whether or not artificially lowering blood pressure using hypotensive agents is advantageous in hypertensive patients; further, the indication for the blood pressure reduction is argued.
    Part of this paper was presented at the 18th Annual Meeting of the Japanese Circulation Society at Nagoya, April 1954. The expense of this study was in part defrayed by a grant in Aid for Medical Research from the Medical Affairs Bureau, Welfare Ministry.
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  • Katsutaro Kobayashi
    1956 Volume 63 Issue 2-3 Pages 185-189
    Published: February 25, 1956
    Released: November 28, 2008
    JOURNALS FREE ACCESS
    The presence of specific antigens in the alcohol extract of human gastric cancer has been demonstrated.
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  • Katsutaro Kobayashi
    1956 Volume 63 Issue 2-3 Pages 191-202
    Published: February 25, 1956
    Released: November 28, 2008
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    1. The specific antigenicity demonstrated in the alcohol extract of human gastric cancer was traced by preparing rabbit antisera against alcohol extracts of human gastric cancer, normal gastric mucosa, performing complement fixation tests of these antisera, aided by absorption tests, with chemical fraction of the extracts, and continuing the fractionation until the fraction responsible for the specific antigenicity could give a single peak in an electrophoretic pattern when submitted to electro-phoresis.
    2. Two substances specific to human gastric cancer have been isolated. They are closely related with each other. Each substance is a single one (not a mixture of two or more substances), presumably consisting of phospholipid and glycolipid.
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  • Katsutaro Kobayashi, Hiroya Kawasaki
    1956 Volume 63 Issue 2-3 Pages 203-220
    Published: February 25, 1956
    Released: November 28, 2008
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    With a view to tracing the specific antigenicity of human gastric cancer a series of experiments were carried out, which essentially consisted of (1) producing antisera in rabbits by injection of saline extracts of human gastric cancer, normal gastric mucosa, and placenta, (2) preparing several purified fractions of the above three kinds of tissue, which were used as antigens for precipitin tests, and (3) performing reciprocal precipitin tests aided by reciprocal absorption tests. It has been demonstrated that the nucleic acid fraction of human gastric cancer presented the highest antigenic specificity, the glucidamin fraction a modertae, and the carbohydrate fraction least specificity.
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  • Tomoki Komiyama
    1956 Volume 63 Issue 2-3 Pages 221-224
    Published: February 25, 1956
    Released: November 28, 2008
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  • Toshiyuki Ozaki
    1956 Volume 63 Issue 2-3 Pages 225-228
    Published: February 25, 1956
    Released: November 28, 2008
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    Activity ratios of adrenaline to noradrenaline in various chemical methods, such as the permanganate, the corrosive sublimate, the iodine, the phosphotungstic acid and arsenomolybdic acid methods were estimated.
    The mean value (adrenaline: noradrenaline) obtained was 1.16:1 in the permanganate method, 1.31:1 in the corrosive sublimate method, 2.4:1 in the iodine method, 2.17:1 in the phosphotungstic acid method and 7.6:1 in the arsenomolybdic acid method.
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  • Ikuro Ito
    1956 Volume 63 Issue 2-3 Pages 229-239
    Published: February 25, 1956
    Released: November 28, 2008
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  • Toshiyuki Ozaki
    1956 Volume 63 Issue 2-3 Pages 241-243
    Published: February 25, 1956
    Released: November 28, 2008
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    In dogs of 2-7 days old as well as those of 20-30 days old, the nor-adrenaline and adrenaline contents of the adrenals were estimated by means of the permanganate method.
    It was found that the relative noradrenaline content of the adrenals in young dogs was invariably larger than that in adult dogs.
    The auther wishes to acknowledge the helpful suggestions of Prof. T. Suzuki.
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  • Zenryu Tanaka
    1956 Volume 63 Issue 2-3 Pages 245-250
    Published: February 25, 1956
    Released: November 28, 2008
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    Electrophoretic study of the protein components in the normal cere-brospinal fluid was reported. In 4 of 19 cases, a rapidly migrating component was observed. The fast components were comprised to about 1.5% in the total spinal fluid proteins. The percentage composition of the spinal fluid protein was as follows: X, 1.5; albumin, 52.8; alpha-albumin, 7.3;
    TABLE II
    Concentration of the Protein Components of Normal Cerebrospinal Fluid
    beta-globulin, 15.9; and gamma-globulin, 23.6. The albumin/globulin quotient in the normal cerebrospinal fluid was 1.2 in meaned value.
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  • Kozo Watanabe
    1956 Volume 63 Issue 2-3 Pages 251-258
    Published: February 25, 1956
    Released: November 28, 2008
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  • Ikuro Tanaka
    1956 Volume 63 Issue 2-3 Pages 259-263
    Published: February 25, 1956
    Released: November 28, 2008
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    In non-anesthetized and non-fastened dogs, DL-noradrenaline was in-jected intravenously in a dose varying from 3μg. to 30μg. per kg. of body weight per minute for 10 minutes at a uniform rate and blood sugar con-tent before and after noradrenaline injection was estimated.
    The minimum effective dose of DL-noradrenaline for causing the in-crease of blood sugar content was found to be 15μg. per kg. per minute.
    My thanks are due to Prof. T. Suzuki for his helpful advice.
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  • Yoshihiko Umehara
    1956 Volume 63 Issue 2-3 Pages 265-276
    Published: February 25, 1956
    Released: November 28, 2008
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    In order to investigate the intermediate metabolism of water, proteins, carbohydrates and electrolytes, in the kidney in experimental hyper-tension, the contents of these substances in the renal venous blood were estimated and compared with those in the arterial blood in normal rabbits as well as in the rabbits made hypertensive by the method of Goldblatt. The comparison of the corresponding data taken from both kinds of animals revealed following facts.
    1. The release of water from the circulating blood into the kidney tends to be somewhat decreased in hypertensive animals.
    2. The discharge of proteins from the blood into the kidney is aug-mented in hypertension. This increment is mainly due to albumin; on the contrary, globulin, especially β- and γ-globulin are transferred in a large quantity from the kidney into the circulating blood.
    3. The discharge of blood non-protein nitrogen into the kidney tends to be reduced in hypertensive animals.
    4. In hypertensive animals, the release of blood sugar into the kidney is augmented, while that of lactic acid is decreased.
    5. Of the electrolytes in blood, the release of Cl and Na into the kidney is below normal; in some cases Cl and Na are transferred, though a little, in the reverse direction so that their contents in the renal vein are increased over those in arterial blood. The transfer of K and Ca into the kidney is increased over normal.
    6. The rise of pH during the intrarenal circulation tends to be slightly augmented in hypertensive cases.
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  • Masao Miura
    1956 Volume 63 Issue 2-3 Pages 277-287
    Published: February 25, 1956
    Released: November 28, 2008
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  • Masao Miura
    1956 Volume 63 Issue 2-3 Pages 289-295
    Published: February 25, 1956
    Released: November 28, 2008
    JOURNALS FREE ACCESS
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  • Yoshiro Hamada
    1956 Volume 63 Issue 2-3 Pages 297-303
    Published: February 25, 1956
    Released: November 28, 2008
    JOURNALS FREE ACCESS
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