Abstract
1. The capillary permeabilities for fluid, protein and its fractions in plasma were estimated in 41 hypertensive patients including essential hypertension, chronic glomerulonephritis and nephropathia gravidarum together with 13 normal adults, under the congestion brought about, according to Landis's method, with pressure of 60 or 80mm. Hg for 15 or 30min.
2. The fluid and protein losses through the capillary wall during the congestion in benign or intermediate hypertension were in general similar to normal. Neither fluid nor protein losses were augmented in malign hypertension and hypertensive nephropathia gravidarum, con-trary to hypertensive chronic glomerulonephritis with also similarly de-creased hemoglobin content of the blood, in which increased fluid and protein losses could be confirmed.
3. It could not be ascertained any correlation between fluid or protein losses and edema, electrocardiographic change, plasma protein content or systolic and diastolic blood pressure.
4. A correlation existed between fluid loss and protein loss above the range of about 10cc. per 100cc. blood in fluid loss.
5. In the cases showing protein loss above 0.2g. per 100cc. blood the ratios of protein fractions in capillary filtrate were almost the same with that in plsma before stasis. Below 0.2g. chifly albumin was transferred to the tissue. These changes did not differ between the type or stage in hypertension, and depended on the intensity of protein loss.
Part of this paper was presented at the 19th annual meeting of the Japanese Circulation Society at Kyoto, April 1955. The expense of this study was in part defrayed by Grants in Aid for Fundamental Scientific Research and also, by that for Medical Research, Welfare Ministry.
