1957 年 65 巻 2-3 号 p. 121-129
1. It was demonstrated with 21 rabbits that causation of alkalosis, ligation of the carotid artery, administration of excess water, and acetylcholine application to the cerebral cortex were capable of increasing the predisposition to convulsions. Examination was made of the action potentials of the autonomic nerves and the brain under these five conditions (including intravenous injection of metrazol alone).
2. From the changes in action potential of the autonomic nerves, the conditions for increasing the predisposition to convulsions may be classified into three types: sympathetic, sympathetic-parasympathetic, and parasympathetic. Under a condition of increasing the predisposition to convulsions, there is brought about a state of unbalance in action potential between the sympathetic and the parasympathetic, In this respect, the importance of the excessively tonic state of the sympathetic has been emphasized.
3. Causation of alkalosis and application of acetylcholine to the cerebral cortex belong to the sympathetic type, and are characterized by a decrease of fast waves (39.2 to 24 cycles per second) in the sympathetic.
4. Intravenous injection of metrazol and ligation of the carotid artery belong to the sympathetic-parasympathetic type, and are characterized by a decrease of fast waves (39.2 to 24 cycles per second) in the sympathetic and an increase of intermediate waves (15.5 to 9.8 cycles per second) in the vagus.
5. Administration of excess water belongs to the parasympathetic type, and is characterized by an increase of intermediate waves (15.5 to 9.8 cycles per second) in the vagus.
6. The changes in the EEG under conditions for increasing the predisposition to convulsions are characterized by a prolongation of the period and increase of intermediate waves (15.5 to 6.2 cycles per second) and slow waves (6.2 to 2.4 cycles per second).
