Relationships of the Predisposition to Convulsions with the Action Potentials of the Autonomic Nerves and the Brain

I. Effects of Several Autonomic Drugs on the Predisposition to Convulsions, the Action Potentials of the Autonomic Nerves and the Brain

抄録

1. Five “autonomic drugs;” (adrenalin, pilocarpine, atropine, hexamethonium, and chlorpromazine) were tested, with 25 adult rabbits, for their effects on the predisposition to convulsions and the relations of these effects with the action potentials of the autonomic nerves and the brain.
2. The predisposition of the same rabbit to convulsions remained almost unchanged within a short period of time. In the frequency histogram for each action potential, the peak was always situated between 39.2 and 24 cycles per second.
3. Of the two types of the autonomic nerves, the sympathetic had the largest effect: its overaction increased predisposition to convulsions, and its inhibition decreased it.
4. The “autonomic drugs” used had selective effects on the action potentials of the autonomic nerves:
a) Adrenalin decreased sympathetic fast waves (39.2 to 24 cycles per second).
b) Pilocarpine increased vagus intermediate waves (15.5 to 9.8 cycles per second).
c) Atropine increased vagus fast waves (39.2 cycles or more per second).
d) Hexamethonium and chlorpromazine decreased amplitude and increased fast waves (39.2 cycles or more per second) of both nerves.
5. In electroencephalograms, there were observed an increase of slow waves (6.2 to 3.9 cycles per second) by adrenalin, an increase of intermediate waves (15.5 to 9.8 cycles per second) by pilocarpine, no remarkable change by atropine, and a prolongation of the period by hexamethonium and chlorpromazine. Direct relations with the predisposition to convulsions could hardly be seen.