Abstract
1. In order to clarify the destroying mechanism of the homotransplanted kidney, cross circulation between nonanesthetized homologous species were carried out following experimental homotransplantation of the kidney.
2. All cross-circulated animals died between 12-144 hours after cross circulation. Their liver, kidney and brain showed the same pathological findings as that in the transplanted kidney.
3. In our first report with homotransplantation of the kidney, the same pathological picture occurred in the recipient liver and kidney as well as in the transplanted kidney. According to the present experimental results, a resembling pathological findings was observed in the transplanted kidney itself, recipient liver and kidney, and vital organs in the cross-circulated animals.
4. This resembling pathological finding common to the 3 organs is an artificial product which cannot be observed in clinical pathological materials, which is probably allergic or toxic products.
5. The reason hat a resembling pathological picture will occurr is probably due to that the 3 organs are placed in the same circulatory pattern. The mechanism of destruction of homotransplanted kidney may have occurred under the same condition. In such circulatory pattern, homologous immunity phenomenon may occur, which needs further studies to verify.
6. Our results and opinion based on these observations are a new finding which we couldn't find in he literature as far as we could look for.
