Abstract
The present investigations were performed on bilaterally splanchnectomized rabbits.
1. Whether 0.1-0.3 mgrm. adrenaline in full strength (1:1, 000) is administered to the rabbit hypodermically or intravenously, or whether 0.1mgrm. or 0.3mgrm. is dosaged for kilo of body weight has no bearing upon either the strength or the duration of hyperglycaemia.
As is well known, the hypodermical application of adrenaline brings about an intensive diuresis and glycosuria, while by the intravenous injection the urine secretion is greatly diminished and the sugar output in urine increases only a little.
2. Anintravenous infusion of a large quantity of the dilute adrenaline saline solution, the total adrenaline quantity being dosaged as 0.1 mgrm. per kilo of body weight to 0.3 mgrm., without narcotic, also results in hyperglycaemia; if the blood sugar content in this series of experiments be calculated to the state of the initial haemoglobin content of blood, the dilution of the blood being taken into consideration, the maximum blood sugar content due to adrenaline does not materially differ from that yielded by the same dose of the drug in full strength (1:1, 000).
3. The epinephrine load of the denervated suprarenal glands is not influenced by infusion of the dilute adrenaline saline solution.
