Abstract
With the aim of furnishing fundamental data for cytological diagnosis of gastric cancer, two experiments were made. In one, direct smear preparations were made from the cancerous and non-cancerous foci of the stomach which had undergone a gastric resectomy and were examined to establish the criteria of malignancy based on cytological features. It became thereby apparent that no single criterion is sufficient to establish conclusively the presence of malignancy, but the fulfillment of a number of criteria provide sufficient evidence for malignancy. In the other experiment, the action of various types of mounting media on cancer cells was studied with phase-contrast microscopy. It was thereby clearly indicated that 5% glucose solution and human blood plasma are commendable as medium for keeping the specimens for cytological diagnosis of gastric cancer, as well as that the presence of both free hydrochloric acid and pepsin seems to play an important parts in inducing cellular damage.
