Cholesterol Transport Mechanism of Hypercholesterolemia in Cholesterol-Fed Chicks

Abstract

Cholesterol content was highest in albumin and α-globulin in chicks on commercial mash diet containing 5% cottonseed oil. When serum cholesterol level is raised by cholesterol feeding, cholesterol accumulates at first in β₁-globulin and then α₂-globulin.
In chicks on regular mash diet to which 5% cottonseed oil was added and in cholesterol-fed chicks, the ratio of β-lipoprotein to α-lipoprotein determined by paper electrophoresis does not reflect exactly the ratio of β-lipoprotein cholesterol to α-lipoprotein cholesterol, because not only cholesterol but also a large quantity of sudanophile lipids accumulates in β-lipoprotein.